Clinically significant response on positive symptoms at least 50% MS improvement · schizophrenia
Adjunctive lithium + antipsychotics showed no clear difference in clinically significant response on positive symptoms at least 50% MS… compared with placebo/no adjunctive treatment + antipsychotics (low certainty).
1 finding from 1 review
Kidney dysfunction outcome not available in any study · schizophrenia
The review found no eligible studies for this question.
1 finding from 1 review
Thyroid dysfunction outcome not available in any study · schizophrenia
The review found no eligible studies for this question.
1 finding from 1 review
Tardive dyskinesia: No clinically important improvement · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
It is very uncertain whether reduced dose of antipsychotics changes tardive dyskinesia: no clinically important improvement compared with antipsychotic maintenance (very low certainty).
1 finding from 1 review
Tardive dyskinesia: Deterioration of symptoms · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
It is very uncertain whether reduced dose of antipsychotics changes tardive dyskinesia: deterioration of symptoms compared with antipsychotic maintenance (very low certainty).
1 finding from 1 review
General mental state: relapse · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
It is very uncertain whether reduced dose of antipsychotics changes general mental state: relapse compared with antipsychotic maintenance (very low certainty).
1 finding from 1 review
RR 3 [0.16, 57.36]
1 study · 8 participants
Very low
Adverse effect: any ‐ not reported · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
1 finding from 1 review
Adverse effect: extrapyramidal symptoms ‐ not reported · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
1 finding from 1 review
Leaving the study early · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
It is very uncertain whether reduced dose of antipsychotics changes acceptability of the treatment: leaving the study early compared with antipsychotic maintenance (very low certainty).
1 finding from 1 review
RR 0.33 [0.06, 1.99]
1 study · 8 participants
Very low
Social confidence, social inclusion, social networks, or personalised quality of life ‐ not reported · female and male 42 (mean) years old patients with schizophrenia or schizoaffective disorder and antipsychotic‐induced tardive dyskinesia
1 finding from 1 review
Irritability · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…
1 finding from 1 review
Aggression · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…
1 finding from 1 review
Self‐injury · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…
1 finding from 1 review
Adverse effects (AEs) · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…
Atypical antipsychotics may leads to higher adverse effects (AEs) compared with placebo (low certainty).
1 finding from 1 review
Gambling symptom severity · treatment of disordered and problem gambling
1 finding from 1 review
Gambling expenditure · treatment of disordered and problem gambling
1 finding from 1 review
Gambling frequency ‐ not measured · treatment of disordered and problem gambling
1 finding from 1 review
Time spent gambling ‐ not measured · treatment of disordered and problem gambling
1 finding from 1 review
Depressive symptoms · treatment of disordered and problem gambling
1 finding from 1 review
Anxiety · treatment of disordered and problem gambling
1 finding from 1 review