Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 2 · 33.3%Moderate 3 · 50%High 0 · 0%

Antidepressants plus benzodiazepines vs antidepressants alone

Depression severity ‐ mean EPDS score (early phase, < 5 weeks) · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 598 participants
Moderate

Antidepressants plus benzodiazepines vs antidepressants alone

Depression severity (acute phase, 5 ≤ 12 weeks) · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 347 participants
Low

Antidepressants plus benzodiazepines vs antidepressants alone

Depression severity: continuous phase (> 12 weeks) · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Antidepressants plus benzodiazepines vs antidepressants alone

Acceptability ‐ total dropouts · patients with major depression

Antidepressants plus benzodiazepines showed no clear difference in acceptability of treatment (dropout for any reason) compared with antidepressants alone (moderate certainty).

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
RR 0.76 [0.54, 1.07]
10 studies · 731 participants
Moderate

Antidepressants plus benzodiazepines vs antidepressants alone

Anxiety · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 129 participants
Very low

Antidepressants plus benzodiazepines vs antidepressants alone

Adverse effects (dropouts) · patients with major depression

Antidepressants plus benzodiazepines probably leads to lower adverse effects (dropouts) compared with antidepressants alone (moderate certainty).

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
RR 0.54 [0.32, 0.9]
10 studies · 731 participants
Moderate