Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Drugs and Alcohol

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No studies found 0 · 0%GRADE not reported 1 · 25%Very low 2 · 50%Low 1 · 25%Moderate 0 · 0%High 0 · 0%

Tricyclic antidepressants vs placebo

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether tricyclic antidepressants changes benzodiazepine discontinuation, end of intervention compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users 2018 · Cochrane Headline outcomes only
RR 0.82 [0.52, 1.28]
2 studies · 105 participants
Very low

Tricyclic antidepressants vs placebo

Benzodiazepine discontinuation, longest · adults who withdraw from chronic benzodiazepine use

Tricyclic antidepressants may leads to higher benzodiazepine discontinuation, longest compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users 2018 · Cochrane Headline outcomes only
RR 2.2 [1.27, 3.82]
1 study · 47 participants
Low

Tricyclic antidepressants vs placebo

Benzodiazepine withdrawal symptoms, end of intervention · adults who withdraw from chronic benzodiazepine use

1 finding from 1 review

Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Very low

Tricyclic antidepressants vs placebo

Benzodiazepine withdrawal symptoms, longest · adults who withdraw from chronic benzodiazepine use

1 finding from 1 review

Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users 2018 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported