Antidepressants vs placebo
Depression at endpoint · patients with depression and dementia
1 finding from 1 review
- no estimate extracted8 studies · 614 participantsHigh
Findings
What do systematic reviews say?
7 questions · 7 findings · 1 reviews · Headline outcomes only
No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 4 · 57.1%High 2 · 28.6%
Antidepressants vs placebo
Number of responders · patients with depression and dementia
Antidepressant treatment showed no clear difference in number of responders (ITT) at 6 to 12 weeks compared with placebo (low certainty).
1 finding from 1 review
- OR 1.71 [0.8, 3.67]3 studies · 116 participantsLow
Antidepressants vs placebo
Remission · patients with depression and dementia
Antidepressant treatment probably leads to higher number of patients with remission (ITT) at 6 to 12 weeks compared with placebo (moderate certainty).
1 finding from 1 review
- OR 2.574 studies · 240 participantsModerate
Antidepressants vs placebo
Cognitive function · patients with depression and dementia
1 finding from 1 review
- no estimate extracted5 studies · 194 participantsModerate
Antidepressants vs placebo
Activities of daily living · patients with depression and dementia
1 finding from 1 review
- no estimate extracted4 studies · 173 participantsHigh
Antidepressants vs placebo
Dropout · patients with depression and dementia
Antidepressant treatment probably leads to higher number of dropouts at 6 to 13 weeks compared with placebo (moderate certainty).
1 finding from 1 review
- OR 1.51 [1.07, 2.14]9 studies · 836 participantsModerate
Antidepressants vs placebo
Risk for at least one adverse event per patient · patients with depression and dementia
Antidepressant treatment probably leads to higher number of patients experiencing at least one adverse event compared with placebo (moderate certainty).
1 finding from 1 review
- OR 1.55 [1.21, 1.98]5 studies · 1073 participantsModerate