Findings

What do systematic reviews say?

249 questions · 257 findings · 31 reviews

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No studies found 52 · 20.2%GRADE not reported 5 · 1.9%Very low 81 · 31.5%Low 77 · 30%Moderate 34 · 13.2%High 8 · 3.1%

Antidepressants vs treatment

Adverse events · women of any age, with PND up to 12 months

1 finding from 1 review

Antidepressant treatment for postnatal depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Antidepressants vs a combination of medications

Severity/intensity of MUPS (post‐treatment score on self report scales) Different self report and clinician‐rated scales (SOMS‐7, SCL‐90 Somatisation Score) · somatoform disorders in adults

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 107 participants
Low

Antidepressants vs a combination of medications

Acceptability · somatoform disorders in adults

Antidepressants showed no clear difference in acceptability (all‐cause drop‐outs4) compared with a combination of medications (low certainty).

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
RR 0.8 [0.25, 2.52]
2 studies · 118 participants
Low

Antidepressants vs a combination of medications

Anxiety · somatoform disorders in adults

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 107 participants
Very low

Antidepressants vs a combination of medications

Depression (post‐treatment score on self report and clinician‐rated scales) Different self report and clinician‐rated scales (HDRS, BDI) · somatoform disorders in adults

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 107 participants
Very low

Antidepressants vs a combination of medications

Withdrawals due to adverse events · somatoform disorders in adults

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs a combination of medications

Treatment response (post‐treatment score on self report and clinician‐rated scales) · somatoform disorders in adults

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs a combination of medications

Quality of life at post‐treatment Indexed by self‐report measures of quality of life or functional disability · somatoform disorders in adults

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for somatoform disorders in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs placebo according to any definition

Dropout · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants showed no clear difference in dropout ‐ All studies objective compared with placebo according to any definition (low certainty).

1 finding from 1 review

Pharmacological treatment for depression during opioid agonist treatment for opioid dependence 2010 · Cochrane Headline outcomes only
RR 1.15 [0.88, 1.51]
6 studies · 406 participants
Low

Antidepressants vs placebo

Severity of depression continuous measures ‐ HDRS total score at the end of the treatment · patients with depression during opioid agonist treatment for opioid dependence

1 finding from 1 review

Pharmacological treatment for depression during opioid agonist treatment for opioid dependence 2010 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 276 participants
Moderate

Antidepressants vs placebo

Adverse events ‐ Withdrawn for medical reasons · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants probably leads to higher adverse events ‐ Withdrawn for medical reasons compared with placebo (moderate certainty).

1 finding from 1 review

Pharmacological treatment for depression during opioid agonist treatment for opioid dependence 2010 · Cochrane Headline outcomes only
RR 3.03 [1.2, 7.68]
3 studies · 276 participants
Moderate

Antidepressants vs placebo according to any definition

Dropout ‐ Studies with low risk of bias · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants showed no clear difference in dropout ‐ Studies with low risk of bias compared with placebo according to any definition (high certainty).

1 finding from 1 review

Pharmacological treatment for depression during opioid agonist treatment for opioid dependence 2010 · Cochrane Headline outcomes only
RR 1.4 [1, 1.96]
4 studies · 325 participants
High

Antidepressants vs placebo according to any definition

> 50% reduction in depressive symptoms · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants showed no clear difference in severity of depression dichotomous measures ‐ >50% reduction in… compared with placebo according to any definition (low certainty).

1 finding from 1 review

Pharmacological treatment for depression during opioid agonist treatment for opioid dependence 2010 · Cochrane Headline outcomes only
RR 0.96 [0.54, 1.71]
1 study · 95 participants
Low

Antidepressants vs placebo according to any definition

Severity of depression dichotomous measures ‐ "very much" or "much" improved on the Clinical Global Impression Scale · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants may leads to higher severity of depression dichotomous measures ‐ "very much" or "much"… compared with placebo according to any definition (low certainty).

1 finding from 1 review

Pharmacological treatment for depression during opioid agonist treatment for opioid dependence 2010 · Cochrane Headline outcomes only
RR 1.92 [1.26, 2.94]
2 studies · 183 participants
Low

Antidepressants vs placebo according to any definition

Severity of depression continuous measures ‐ HDRS total score at the end of the treatment · patients with depression during opioid agonist treatment for opioid dependence

1 finding from 1 review

Pharmacological treatment for depression during opioid agonist treatment for opioid dependence 2010 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 346 participants
Low

Antidepressants vs placebo according to any definition

Adverse events ‐ Withdrawn for medical reasons · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants probably leads to higher adverse events ‐ Withdrawn for medical reasons compared with placebo according to any definition (moderate certainty).

1 finding from 1 review

Pharmacological treatment for depression during opioid agonist treatment for opioid dependence 2010 · Cochrane Headline outcomes only
RR 2.9 [1.23, 6.86]
4 studies · 311 participants
Moderate

Antidepressants vs placebo

Dropout · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants showed no clear difference in dropout compared with placebo (moderate certainty).

1 finding from 1 review

Pharmacological treatment for depression during opioid agonist treatment for opioid dependence 2010 · Cochrane Headline outcomes only
RR 1.2 [0.88, 1.64]
4 studies · 322 participants
Moderate

Antidepressants vs placebo

Antidepressants may leads to higher severity of depression dichotomous measures ‐ "very much" or "much"… compared with placebo (low certainty).

1 finding from 1 review

Pharmacological treatment for depression during opioid agonist treatment for opioid dependence 2010 · Cochrane Headline outcomes only
RR 2.03 [1.17, 3.53]
1 study · 137 participants
Low

Antidepressants vs placebo

> 50% reduction in depressive symptoms · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants showed no clear difference in severity of depression dichotomous measures ‐ >50% reduction in… compared with placebo (low certainty).

1 finding from 1 review

Pharmacological treatment for depression during opioid agonist treatment for opioid dependence 2010 · Cochrane Headline outcomes only
RR 0.96 [0.54, 1.71]
1 study · 95 participants
Low

Antidepressants plus benzodiazepines vs antidepressants alone

Depression severity ‐ mean EPDS score (early phase, < 5 weeks) · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 598 participants
Moderate