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What do systematic reviews say?

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Evidence found and GRADE certainty

30 questions · 36 findings · 4 reviews

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No studies found 6 · 16.7%GRADE not reported 1 · 2.8%Very low 5 · 13.9%Low 10 · 27.8%Moderate 9 · 25%High 5 · 13.9%

Non‐vitamin‐K‐antagonist oral anticoagulants vs placebo

Apixaban (all doses combined) vs placebo · adults after AMI without an indication for anticoagulation
3 findings from 1 review

Non‐vitamin‐K‐antagonist oral anticoagulants vs placebo

Rivaroxaban (all doses combined) vs placebo · adults after AMI without an indication for anticoagulation
3 findings from 1 review

Non‐vitamin‐K‐antagonist oral anticoagulants vs placebo

Dabigatran (all doses combined) vs placebo · adults after AMI without an indication for anticoagulation
3 findings from 1 review

Anticoagulants (chosen at investigators' discretion) vs placebo

Symptomatic VTE · people requiring prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair

Anticoagulants (chosen at investigators' discretion) showed no clear difference in symptomatic VTE (DVT and PE) Treatment duration 28 ‐ 42 days compared with placebo (low certainty).

1 finding from 1 review

Anticoagulants (chosen at investigators' discretion) vs placebo

Symptomatic DVT · people requiring prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair

Anticoagulants (chosen at investigators' discretion) showed no clear difference in symptomatic DVT (proximal or distal) Treatment duration 28 ‐ 42 days compared with placebo (low certainty).

1 finding from 1 review

Anticoagulants (chosen at investigators' discretion) vs placebo

Symptomatic PE Treatment duration 28 ‐ 42 days · people requiring prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair

Anticoagulants (chosen at investigators' discretion) showed no clear difference in symptomatic PE Treatment duration 28 ‐ 42 days compared with placebo (low certainty).

1 finding from 1 review

Anticoagulants (chosen at investigators' discretion) vs placebo

Major bleeding · people requiring prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair

Anticoagulants (chosen at investigators' discretion) showed no clear difference in bleeding ‐ major Treatment duration 28 ‐ 42 days compared with placebo (low certainty).

1 finding from 1 review

Anticoagulants (chosen at investigators' discretion) vs placebo

Clinically relevant non‐major bleeding Treatment duration 28 ‐ 42 days · people requiring prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair

The review found no eligible studies for this question.

1 finding from 1 review