Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Incontinence

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 3 · 42.9%High 0 · 0%

Anticholinergic medication vs placebo

Disease‐specific quality of life · Adults with overactive bladder (OAB)

Anticholinergics showed no clear difference in mean change from baseline in condition‐specific quality of lifeScale… compared with placebo (low certainty).

1 finding from 1 review

Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults 2023 · Cochrane Headline outcomes only
MD 4.41
12 studies · 6804 participants
Low

Anticholinergic medication vs placebo

Perception of improvement or cure · Adults with overactive bladder (OAB)

Anticholinergics probably leads to higher patient perception of cure or improvement compared with placebo (moderate certainty).

1 finding from 1 review

Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults 2023 · Cochrane Headline outcomes only
RR 1.38 [1.15, 1.66]
9 studies · 8457 participants
Moderate

Anticholinergic medication vs placebo

Number of urgency episodes per 24 hours: immediately after treatment · Adults with overactive bladder (OAB)

Anticholinergics showed no clear difference in mean number of urgency episodes per 24 hours compared with placebo (moderate certainty).

1 finding from 1 review

Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults 2023 · Cochrane Headline outcomes only
MD 0.85
23 studies · 16875 participants
Moderate

Anticholinergic medication vs placebo

Adverse effects: dry mouth · Adults with overactive bladder (OAB)

Anticholinergics may leads to higher adverse events: dry mouth compared with placebo (low certainty).

1 finding from 1 review

Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults 2023 · Cochrane Headline outcomes only
RR 3.5 [3.26, 3.75]
66 studies · 38368 participants
Low

Anticholinergic medication vs placebo

Adverse events:urinary retention · Adults with overactive bladder (OAB)

Anticholinergics may leads to higher adverse events:urinary retention compared with placebo (low certainty).

1 finding from 1 review

Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults 2023 · Cochrane Headline outcomes only
RR 3.52 [2.04, 6.08]
17 studies · 7862 participants
Low

Anticholinergic medication vs placebo

Withdrawals due to adverse events · Adults with overactive bladder (OAB)

Anticholinergics may leads to higher withdrawal due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults 2023 · Cochrane Headline outcomes only
RR 1.37 [1.21, 1.56]
61 studies · 36943 participants
Low

Anticholinergic medication vs placebo

Number of micturition episodes per 24 hours: immediately after treatment · Adults with overactive bladder (OAB)

Anticholinergics showed no clear difference in mean number of micturitions per 24 hours compared with placebo (moderate certainty).

1 finding from 1 review

Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults 2023 · Cochrane Headline outcomes only
MD 0.85
30 studies · 19395 participants
Moderate