Antibiotics (systemic) vs No antibiotics, placebo, or a different type of antibiotic
Outcome not reported · Patients (mainly children and young adults) with a history of dental trauma and a diagnosis of luxation (intrusion, extrusion, or lateral…
The review found no eligible studies for this question.
1 finding from 1 review
Prosthesis failure · Adults undergoing dental implant placement
Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in prosthesis failure compared with no antibiotics or placebo; GRADE not reported.
1 finding from 1 review
Postoperative infection · Adults undergoing dental implant placement
Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in postoperative infection compared with no antibiotics or placebo; GRADE not reported.
1 finding from 1 review
Implant failure · Adults undergoing dental implant placement
Prophylactic systemic antibiotics (amoxicillin) probably leads to lower implant failure compared with no antibiotics or placebo (moderate certainty).
1 finding from 1 review
Adverse events · Adults undergoing dental implant placement
Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in adverse events compared with no antibiotics or placebo; GRADE not reported.
1 finding from 1 review
Systemic antibiotics without surgical intervention (with or without analgesics) vs Matched placebo without surgical intervention (with or without analgesics)
Outcome not reported · Adults with symptomatic apical periodontitis or acute apical abscess
The review found no eligible studies for this question.
1 finding from 1 review
Swelling (mean) · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
The review found no eligible studies for this question.
3 findings from 1 review
No data available for this outcome.
0 studies
No studies found
RR 0.50 [0.10, 2.56]
1 study · 72 participants
Low
No data available for this outcome.
0 studies
No studies found
Pain at 24 hours · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
1 finding from 1 review
The median pain at 24 hours in the control group was 3 (range 0 to 10); the median pain at 24 hours in the intervention group was the same (median 3, range 0 to 8). P = 0.219 (Mann-Whitney U).
1 study · 72 participants
Low
Pain at 48 hours · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
1 finding from 1 review
Analgesic (painkiller) use · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
Single preoperative dose of systemic antibiotics (clindamycin 600… showed no clear difference in analgesic use compared with matched placebo, total chemo-mechanical debridement and root filling; GRADE not reported.
1 finding from 1 review
Pain at 72 hours · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
1 finding from 1 review
The median pain at 72 hours in the control group was 0 (range 0 to 10); the median pain at 72 hours in the intervention group was the same (median 0, range 0 to 7). P = 0.116 (Mann-Whitney U).
1 study · 72 participants
Low
Adverse effects · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
1 finding from 1 review
Pain at 7 days · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
1 finding from 1 review
The median pain at 7 days in the control group was 0 (range 0 to 3); the median pain at 7 days in the intervention group was the same (median 0, range 0 to 1). P = 0.673 (Mann-Whitney U).
1 study · 72 participants
Low
Number of ibuprofen tablets required · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
Postoperative systemic antibiotics… showed no clear difference in number of ibuprofen tablets required compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
1 finding from 1 review
Percussion pain at 24 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
Postoperative systemic antibiotics… showed no clear difference in percussion pain at 24 hours compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
2 findings from 1 review
Pain at 24 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
It is very uncertain whether postoperative systemic antibiotics… changes pain at 24 hours compared with matched placebo, partial or total chemo-mechanical debridement and… (very low certainty).
1 finding from 1 review
Swelling (mean) · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
Postoperative systemic antibiotics… showed no clear difference in swelling at 48 hours compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
4 findings from 1 review
SMD 0.04 [-0.47, 0.55]
2 studies · 61 participants
GRADE not reported
SMD 0.27 [-0.23, 0.78]
2 studies · 62 participants
Very low
SMD 0.02 [-0.49, 0.52]
2 studies · 61 participants
Very low
Show 1 more finding
Pain at 48 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
Postoperative systemic antibiotics… showed no clear difference in pain at 48 hours compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
1 finding from 1 review
Pain at 72 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
It is very uncertain whether postoperative systemic antibiotics… changes pain at 72 hours compared with matched placebo, partial or total chemo-mechanical debridement and… (very low certainty).
1 finding from 1 review
Percussion pain at 72 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
Postoperative systemic antibiotics… showed no clear difference in percussion pain at 72 hours compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
1 finding from 1 review