Findings

What do systematic reviews say?

8 questions · 8 findings · 2 reviews · Neonatal

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No studies found 2 · 25%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 62.5%Moderate 1 · 12.5%High 0 · 0%

Antibiotics vs no antibiotics

Incidence of confirmed sepsis in first 28 days · symptomatic neonates born through meconium‐stained amniotic fluid

1 finding from 1 review

Antibiotics for neonates born through meconium‐stained amniotic fluid 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 445 participants
Low

Antibiotics vs no antibiotics

Duration of oxygen therapy (hours) · symptomatic neonates born through meconium‐stained amniotic fluid

1 finding from 1 review

Antibiotics for neonates born through meconium‐stained amniotic fluid 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 405 participants
Low

Antibiotics vs no antibiotics

Length of hospital stay · symptomatic neonates born through meconium‐stained amniotic fluid

1 finding from 1 review

Antibiotics for neonates born through meconium‐stained amniotic fluid 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 146 participants
Moderate

Antibiotics vs no antibiotics

Incidence of confirmed sepsis in first 28 days · asymptomatic neonates born through meconium‐stained amniotic fluid

1 finding from 1 review

Antibiotics for neonates born through meconium‐stained amniotic fluid 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 250 participants
Low

Antibiotics vs no antibiotics

Duration of oxygen therapy (hours) · asymptomatic neonates born through meconium‐stained amniotic fluid

1 finding from 1 review

Antibiotics for neonates born through meconium‐stained amniotic fluid 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 250 participants
Low

Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin

Length of stay among survivors · neonates with sepsis

The review found no eligible studies for this question.

1 finding from 1 review

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics

Length of stay among survivors · neonates with sepsis

The review found no eligible studies for this question.

1 finding from 1 review

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Length of hospital stay · neonates with sepsis

Pentoxifylline with antibiotics (any dose or duration) showed no clear difference in length of hospital stay (LOS) in days compared with placebo or no intervention (low certainty).

1 finding from 1 review

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 157 participants
Low