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What do systematic reviews say?

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Evidence found and GRADE certainty

594 questions · 624 findings · 70 reviews

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No studies found 151 · 24.2%GRADE not reported 53 · 8.5%Very low 174 · 27.9%Low 129 · 20.7%Moderate 82 · 13.1%High 35 · 5.6%

Antibiotics vs placebo

Children not cured or substantially improved at · prolonged wet cough in children

Antibiotics probably leads to lower children not cured or substantially improved at compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Children with progression of the disease resulting in additional medical therapy (complications) (measured as proportion of participants) · prolonged wet cough in children

Antibiotics probably leads to lower children with progression of the disease resulting in additional… compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Cure in adults with clinically diagnosed acute rhinosinusitis · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics leads to higher cure in adults with clinically diagnosed acute rhinosinusitis compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Cure in adults with acute rhinosinusitis confirmed by radiography1 · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics probably leads to higher cure in adults with acute rhinosinusitis confirmed by radiography1 compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Cure in adults with acute rhinosinusitis confirmed by computed tomography1,4 · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics probably leads to higher cure in adults with acute rhinosinusitis confirmed by computed… compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Resolution of purulent secretion · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics leads to higher severity or duration of different clinical symptoms: resolution of… compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Side effects – overall · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics leads to higher side effects: total compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Interventions side effects: diarrhoea · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics leads to higher side effects: diarrhoea compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Clinical failure · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics leads to lower clinical failure compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Treatment failure within 4 weeks ‐ current drugs only ‐ inpatient · exacerbations of COPD

Antibiotics showed no clear difference in treatment failure within 4 weeks ‐ current drugs only ‐ inpatient compared with placebo (moderate certainty).

1 finding from 1 review