Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

17 questions · 17 findings · 2 reviews · Implants and prosthodontics

No studies found 1 · 5.9%GRADE not reported 15 · 88.2%Very low 0 · 0%Low 0 · 0%Moderate 1 · 5.9%High 0 · 0%

Prophylactic antibiotic at one dose or duration vs Same antibiotic at a different dose or duration

Outcome not reported · Adults undergoing dental implant placement
1 finding from 1 review

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Prosthesis failure · Adults undergoing dental implant placement

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in prosthesis failure compared with no antibiotics or placebo; GRADE not reported.

1 finding from 1 review

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Postoperative infection · Adults undergoing dental implant placement

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in postoperative infection compared with no antibiotics or placebo; GRADE not reported.

1 finding from 1 review

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Implant failure · Adults undergoing dental implant placement

Prophylactic systemic antibiotics (amoxicillin) probably leads to lower implant failure compared with no antibiotics or placebo (moderate certainty).

1 finding from 1 review

Prophylactic systemic antibiotics (amoxicillin) vs placebo or no antibiotic

Adverse events · Adults undergoing dental implant placement

Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in adverse events compared with no antibiotics or placebo; GRADE not reported.

1 finding from 1 review

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox) added to manual debridement vs Manual debridement plus chlorhexidine irrigation/gel

Change in probing attachment level (PAL) · People with at least one dental implant affected by perimplantitis

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox)… led to higher change in probing attachment level (PAL) compared with manual debridement with chlorhexidine (no antibiotic); GRADE not reported.

1 finding from 1 review

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox) added to manual debridement vs Manual debridement plus chlorhexidine irrigation/gel

Recurrence of peri-implantitis · People with at least one dental implant affected by perimplantitis
1 finding from 1 review

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox) added to manual debridement vs Manual debridement plus chlorhexidine irrigation/gel

Change in probing pocket depth (PPD) · People with at least one dental implant affected by perimplantitis

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox)… led to higher change in probing pocket depth (PPD) compared with manual debridement with chlorhexidine (no antibiotic); GRADE not reported.

1 finding from 1 review

Metronidazole gel 25% (local antibiotic) vs Ultrasonic debridement

Change in probing pocket depth (PPD) · People with at least one dental implant affected by perimplantitis

Metronidazole gel 25% (local antibiotic) showed no clear difference in change in probing pocket depth compared with ultrasonic debridement; GRADE not reported.

1 finding from 1 review

Implant surface smoothening added to systemic antibiotics + resective surgery + local antibiotics vs No implant surface smoothening (same surgical protocol)

Implant failure · People with at least one dental implant affected by perimplantitis

Implant surface smoothening added to systemic antibiotics +… showed no clear difference in implant failure compared with no implant surface smoothening (same surgical protocol); GRADE not reported.

1 finding from 1 review