Serious adverse events Duration 3 days to 3 weeks · acute asthma exacerbation
Antibiotics showed no clear difference in serious adverse events Duration 3 days to 3 weeks compared with placebo or usual care (low certainty).
1 finding from 1 review
Mortality ‐ not reported · acute asthma exacerbation
The review found no eligible studies for this question.
1 finding from 1 review
Length of hospital stay · acute asthma exacerbation
1 finding from 1 review
Relapse ‐ not reported · acute asthma exacerbation
The review found no eligible studies for this question.
1 finding from 1 review
PEFR (GIV) Duration 10 days · acute asthma exacerbation
1 finding from 1 review
Children not cured or substantially improved at · prolonged wet cough in children
Antibiotics probably leads to lower children not cured or substantially improved at compared with placebo (moderate certainty).
1 finding from 1 review
Children with progression of the disease resulting in additional medical therapy (complications) (measured as proportion of participants) · prolonged wet cough in children
Antibiotics probably leads to lower children with progression of the disease resulting in additional… compared with placebo (moderate certainty).
1 finding from 1 review
Cure in adults with clinically diagnosed acute rhinosinusitis · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging
Antibiotics leads to higher cure in adults with clinically diagnosed acute rhinosinusitis compared with placebo (high certainty).
1 finding from 1 review
Cure in adults with acute rhinosinusitis confirmed by radiography1 · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging
Antibiotics probably leads to higher cure in adults with acute rhinosinusitis confirmed by radiography1 compared with placebo (moderate certainty).
1 finding from 1 review
Cure in adults with acute rhinosinusitis confirmed by computed tomography1,4 · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging
Antibiotics probably leads to higher cure in adults with acute rhinosinusitis confirmed by computed… compared with placebo (moderate certainty).
1 finding from 1 review
Resolution of purulent secretion · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging
Antibiotics leads to higher severity or duration of different clinical symptoms: resolution of… compared with placebo (high certainty).
1 finding from 1 review
Side effects – overall · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging
Antibiotics leads to higher side effects: total compared with placebo (high certainty).
1 finding from 1 review
Interventions side effects: diarrhoea · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging
Antibiotics leads to higher side effects: diarrhoea compared with placebo (high certainty).
1 finding from 1 review
Clinical failure · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging
Antibiotics leads to lower clinical failure compared with placebo (high certainty).
1 finding from 1 review
Treatment failure within 4 weeks ‐ current drugs only · exacerbations of COPD
Antibiotics may leads to lower treatment failure within 4 weeks ‐ current drugs only compared with placebo (low certainty).
1 finding from 1 review
Adverse events (timing not specified) · exacerbations of COPD
Antibiotics showed no clear difference in adverse events ‐ overall (any adverse events not specified) compared with placebo overall (moderate certainty).
1 finding from 1 review
All‐cause mortality · exacerbations of COPD
Antibiotics showed no clear difference in all‐cause mortality compared with placebo (low certainty).
1 finding from 1 review
Treatment failure within 4 weeks ‐ current drugs only ‐ inpatient · exacerbations of COPD
Antibiotics showed no clear difference in treatment failure within 4 weeks ‐ current drugs only ‐ inpatient compared with placebo (moderate certainty).
1 finding from 1 review
Treatment failure within 4 weeks ‐ drugs not currently used ‐ ICU · exacerbations of COPD
Antibiotics probably leads to lower treatment failure within 4 weeks ‐ drugs not currently used ‐ ICU compared with placebo (moderate certainty).
1 finding from 1 review
Length of stay (inpatients only) · exacerbations of COPD
1 finding from 1 review