Abnormal tympanometry ‐ 2 to 4 weeks · children with acute otitis media
Antibiotics leads to lower abnormal tympanometry ‐ 2 to 4 weeks compared with placebo (high certainty).
1 finding from 1 review
Abnormal tympanometry ‐ 3 months · children with acute otitis media
Antibiotics showed no clear difference in abnormal tympanometry ‐ 3 months compared with placebo (high certainty).
1 finding from 1 review
Clinical efficacy (RR > 1 is favored) · Participants with acute bacterial conjunctivitis
1 finding from 1 review
no estimate extracted
4 participants
Moderate
Microbiological efficacy (RR > 1 favored) · Participants with acute bacterial conjunctivitis
1 finding from 1 review
no estimate extracted
8 participants
Moderate
Treatment incompletion (RR < 1 favored) · Participants with acute bacterial conjunctivitis
Antibiotics probably leads to lower treatment incompletion (RR < 1 favored) compared with placebo (moderate certainty).
1 finding from 1 review
Persistent clinical infection after one course of treatment (RR < 1 favored) · Participants with acute bacterial conjunctivitis
Antibiotics probably leads to lower persistent clinical infection after one course of treatment (RR < 1… compared with placebo (moderate certainty).
1 finding from 1 review
Cost‐effectiveness of treatment · Participants with acute bacterial conjunctivitis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Treatment‐associated ocular complications (RR < 1 or RD ≤ 0 favored) · Participants with acute bacterial conjunctivitis
It is very uncertain whether antibiotics changes treatment‐associated ocular complications (RR < 1 or RD ≤ 0 favored) compared with placebo (very low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Treatment‐associated systemic complications (RR < 1 favored) · Participants with acute bacterial conjunctivitis
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)
It is very uncertain whether antibiotics changes hearing ‐ return to normal hearing (as complete improvement in… compared with placebo (very low certainty).
1 finding from 1 review
Disease‐specific quality of life · children aged 6 months to 12 years with otitis media with effusion (OME)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)
It is very uncertain whether antibiotics changes presence/persistence of OME compared with placebo (very low certainty).
1 finding from 1 review
RR 0.89 [0.68, 1.17]
Studies not reported
Very low
Adverse event: anaphylaxis · children aged 6 months to 12 years with otitis media with effusion (OME)
It is very uncertain whether antibiotics changes adverse event: anaphylaxis compared with placebo (very low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Hearing · children aged 6 months to 12 years with otitis media with effusion (OME)
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Disease‐specific quality of life · children aged 6 months to 12 years with otitis media with effusion (OME)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)
Antibiotics may leads to lower presence/persistence of OME (up to 3 months) № of participants: 542… compared with no treatment (low certainty).
1 finding from 1 review
RR 0.64 [0.5, 0.8]
Studies not reported
Low
Adverse event: anaphylaxis · children aged 6 months to 12 years with otitis media with effusion (OME)
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Failure to induce clinical remission at end of study · people with active UC
Antibiotics showed no clear difference in failure to induce clinical remission at end of study compared with placebo (high certainty).
1 finding from 1 review
Failure to induce clinical response at end of study · people with active UC
It is very uncertain whether antibiotics changes failure to induce clinical response at end of study compared with 5‐ASA (very low certainty).
1 finding from 1 review
Serious adverse events · people with active UC
1 finding from 1 review