Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

888 questions · 936 findings · 109 reviews

No studies found 196 · 20.9%GRADE not reported 88 · 9.4%Very low 226 · 24.1%Low 217 · 23.2%Moderate 152 · 16.2%High 57 · 6.1%

Antibiotics vs placebo

Interventions side effects: diarrhoea · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics leads to higher side effects: diarrhoea compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Clinical failure · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics leads to lower clinical failure compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Treatment failure within 4 weeks ‐ current drugs only ‐ inpatient · exacerbations of COPD

Antibiotics showed no clear difference in treatment failure within 4 weeks ‐ current drugs only ‐ inpatient compared with placebo (moderate certainty).

1 finding from 1 review