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What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 10 findings · 3 reviews

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No studies found 4 · 40%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 20%Moderate 3 · 30%High 1 · 10%

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Exacerbation frequency · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings: anti‐pseudomonal antibiotics vs placebo

Frequency of hospital admissions for pulmonary exacerbations ‐ not measured · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Summary of findings: anti‐pseudomonal antibiotics may leads to lower pulmonary exacerbations: frequency of one or more hospital admissions compared with placebo (low certainty).

1 finding from 1 review

14 days on/off antibiotic regimen vs 14 days on/off placebo regimen

Exacerbation frequency · people with bronchiectasis

14 days on/off antibiotic regimen probably leads to lower exacerbation frequency compared with 14 days on/off placebo regimen (moderate certainty).

2 findings from 1 review

14 days on/off antibiotic regimen vs 28 days on/off antibiotic regimen

Exacerbation frequency · people with bronchiectasis

14 days on/off antibiotic regimen showed no clear difference in exacerbation frequency compared with 28 days on/off antibiotic regimen (moderate certainty).

2 findings from 1 review

28 days on/off antibiotic regimen vs 28 days on/off placebo regimen

Exacerbation frequency · people with bronchiectasis

28 days on/off antibiotic regimen showed no clear difference in exacerbation frequency compared with 28 days on/off placebo regimen (high certainty).

2 findings from 1 review