Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 1 · 33.3%Moderate 1 · 33.3%High 0 · 0%

All‐cause mortality · adults in sinus rhythm after cardioversion of atrial fibrillation

Amiodarone showed no clear difference in all‐cause mortality compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation 2019 · Cochrane Headline outcomes only
RR 1.66 [0.55, 4.99]
2 studies · 444 participants
Moderate

All‐cause mortality · participants with high risk of sudden cardiac death (primary prevention)

Amiodarone showed no clear difference in all‐cause mortality compared with placebo or no treatment (low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 0.88 [0.78, 1]
17 studies · 8383 participants
Low

All‐cause mortality · participants with high risk of sudden cardiac death (secondary prevention)

It is very uncertain whether amiodarone changes all‐cause mortality compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Amiodarone versus other pharmacological interventions for prevention of sudden cardiac death 2015 · Cochrane Headline outcomes only
RR 3.05 [1.33, 7.01]
2 studies · 440 participants
Very low