Findings

What do systematic reviews say?

4 questions · 4 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 1 · 25%Moderate 2 · 50%High 0 · 0%

Alpha‐blockers vs usual care

Major adverse events · adult patients presenting with symptoms of ureteral stone disease

Alpha‐blockers showed no clear difference in major adverse events compared with standard therapy (low certainty).

1 finding from 1 review

Alpha‐blockers as medical expulsive therapy for ureteral stones 2018 · Cochrane Headline outcomes only
RR 1.25 [0.8, 1.96]
18 studies · 3124 participants
Low

Alpha‐blockers vs placebo

Major adverse events · adult patients presenting with symptoms of ureteral stone disease

Alpha‐blockers probably leads to higher major adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Alpha‐blockers as medical expulsive therapy for ureteral stones 2018 · Cochrane Headline outcomes only
RR 2.09 [1.13, 3.86]
10 studies · 1650 participants
Moderate

Alpha‐blockers vs placebo with/without analgesics

Serious adverse events or complications of treatment

1 finding from 1 review

Medical and surgical interventions for the treatment of urinary stones in children 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 63 participants
Very low

Alpha‐blockers vs placebo

Dropouts due to adverse events · adults (aged 18‐85)

Comparison 1: Alpha‐blockers showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (moderate certainty).

1 finding from 1 review

Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
RR 0.99 [0.91, 1.08]
1 study · 304 participants
Moderate