Findings

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5 questions · 5 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 3 · 60%Very low 0 · 0%Low 2 · 40%Moderate 0 · 0%High 0 · 0%

Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion)

Adverse events · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydrammine led to lower adverse events compared with placebo (Unit of randomisation: transfusion); GRADE not reported.

1 finding from 1 review

Pharmacological interventions for the prevention of allergic and febrile non‐haemolytic transfusion reactions 2010 · Cochrane Headline outcomes only
RR 0 [0, 0]
0 studies · 0 participants
GRADE not reported

Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion)

Fever · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydrammine showed no clear difference in fever ‐ Per protocol analysis compared with placebo (Unit of randomisation: transfusion) (low certainty).

1 finding from 1 review

Pharmacological interventions for the prevention of allergic and febrile non‐haemolytic transfusion reactions 2010 · Cochrane Headline outcomes only
RR 1.77 [0.57, 5.49]
1 study · 98 participants
Low

Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion)

Anaphylatic reactions ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydrammine led to lower anaphylatic reactions ‐ not reported compared with placebo (Unit of randomisation: transfusion); GRADE not reported.

1 finding from 1 review

Pharmacological interventions for the prevention of allergic and febrile non‐haemolytic transfusion reactions 2010 · Cochrane Headline outcomes only
RR 0 [0, 0]
0 studies · 0 participants
GRADE not reported

Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion)

Hives ‐ Per protocol analysis · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydrammine showed no clear difference in hives ‐ Per protocol analysis compared with placebo (Unit of randomisation: transfusion) (low certainty).

1 finding from 1 review

Pharmacological interventions for the prevention of allergic and febrile non‐haemolytic transfusion reactions 2010 · Cochrane Headline outcomes only
RR 0.13 [0.01, 2.39]
1 study · 98 participants
Low

Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion)

Death ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydrammine led to lower death ‐ not reported compared with placebo (Unit of randomisation: transfusion); GRADE not reported.

1 finding from 1 review

Pharmacological interventions for the prevention of allergic and febrile non‐haemolytic transfusion reactions 2010 · Cochrane Headline outcomes only
RR 0 [0, 0]
0 studies · 0 participants
GRADE not reported