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Evidence found and GRADE certainty

5 questions · 5 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 3 · 60%Very low 1 · 20%Low 1 · 20%Moderate 0 · 0%High 0 · 0%

Acetaminophen plus Diphenhydramine vs placebo

Febrile reactions (fever with or without chills, chills with or without rigors) ‐ Intention‐to treat analysis · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydramine showed no clear difference in febrile reactions (fever with or without chills, chills with or… compared with placebo (low certainty).

1 finding from 1 review

Acetaminophen plus Diphenhydramine vs placebo

Anaphylatic reactions ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydramine led to lower anaphylatic reactions ‐ not reported compared with placebo; GRADE not reported.

1 finding from 1 review

Acetaminophen plus Diphenhydramine vs placebo

Death ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydramine led to lower death ‐ not reported compared with placebo; GRADE not reported.

1 finding from 1 review

Acetaminophen plus Diphenhydramine vs placebo

Adverse events · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydramine led to lower adverse events compared with placebo; GRADE not reported.

1 finding from 1 review

Acetaminophen plus Diphenhydramine vs placebo

Allergic reactions (urticaria with or without pruritus) ‐ Intention‐to treat analysis · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

It is very uncertain whether acetaminophen plus Diphenhydramine changes allergic reactions (urticaria with or without pruritus) ‐… compared with placebo (very low certainty).

1 finding from 1 review