Febrile reactions (fever with or without chills, chills with or without rigors) ‐ Intention‐to treat analysis · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydramine showed no clear difference in febrile reactions (fever with or without chills, chills with or… compared with placebo (low certainty).
1 finding from 1 review
Anaphylatic reactions ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydramine led to lower anaphylatic reactions ‐ not reported compared with placebo; GRADE not reported.
1 finding from 1 review
Death ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydramine led to lower death ‐ not reported compared with placebo; GRADE not reported.
1 finding from 1 review
Adverse events · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydramine led to lower adverse events compared with placebo; GRADE not reported.
1 finding from 1 review
Allergic reactions (urticaria with or without pruritus) ‐ Intention‐to treat analysis · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
It is very uncertain whether acetaminophen plus Diphenhydramine changes allergic reactions (urticaria with or without pruritus) ‐… compared with placebo (very low certainty).
1 finding from 1 review
Adverse events · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydrammine led to lower adverse events compared with placebo (Unit of randomisation: transfusion); GRADE not reported.
1 finding from 1 review
Fever · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydrammine showed no clear difference in fever ‐ Per protocol analysis compared with placebo (Unit of randomisation: transfusion) (low certainty).
1 finding from 1 review
Anaphylatic reactions ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydrammine led to lower anaphylatic reactions ‐ not reported compared with placebo (Unit of randomisation: transfusion); GRADE not reported.
1 finding from 1 review
Hives ‐ Per protocol analysis · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydrammine showed no clear difference in hives ‐ Per protocol analysis compared with placebo (Unit of randomisation: transfusion) (low certainty).
1 finding from 1 review
Death ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Acetaminophen plus Diphenhydrammine led to lower death ‐ not reported compared with placebo (Unit of randomisation: transfusion); GRADE not reported.
1 finding from 1 review