Findings

What do systematic reviews say?

8 questions · 8 findings · 1 reviews · Common Mental Disorders

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No studies found 3 · 37.5%GRADE not reported 0 · 0%Very low 5 · 62.5%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Abrupt discontinuation vs continuation of long‐term antidepressants

Successful discontinuation rate · participants with depressive or anxiety disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Abrupt discontinuation vs continuation of long‐term antidepressants

Relapse · participants with depressive or anxiety disorders

It is very uncertain whether abrupt discontinuation changes relapse (as defined by study authors) (HR) compared with continuation of long‐term antidepressants (very low certainty).

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
HR 2.09 [1.59, 2.74]
10 studies · 1373 participants
Very low

Abrupt discontinuation vs continuation of long‐term antidepressants

Withdrawal symptoms · participants with depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 182 participants
Very low

Abrupt discontinuation vs continuation of long‐term antidepressants

Adverse events · participants with depressive or anxiety disorders

It is very uncertain whether abrupt discontinuation changes adverse events compared with continuation of long‐term antidepressants (very low certainty).

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
OR 1.11 [0.62, 1.99]
7 studies · 1012 participants
Very low

Abrupt discontinuation vs continuation of long‐term antidepressants

Depressive symptoms · participants with depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 330 participants
Very low

Abrupt discontinuation vs continuation of long‐term antidepressants

Anxiety · participants with depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 439 participants
Very low

Abrupt discontinuation vs continuation of long‐term antidepressants

Quality of life · participants with depressive or anxiety disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Abrupt discontinuation vs continuation of long‐term antidepressants

Social and occupational functioning · participants with depressive or anxiety disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found