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Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 10 findings · 2 reviews · Headline outcomes only

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No studies found 3 · 30%GRADE not reported 0 · 0%Very low 7 · 70%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Abrupt discontinuation vs continuation of long‐term antidepressants

Relapse · participants with depressive or anxiety disorders

It is very uncertain whether abrupt discontinuation changes relapse (as defined by study authors) (HR) compared with continuation of long‐term antidepressants (very low certainty).

1 finding from 1 review

Abrupt discontinuation vs continuation of long‐term antidepressants

Adverse events · participants with depressive or anxiety disorders

It is very uncertain whether abrupt discontinuation changes adverse events compared with continuation of long‐term antidepressants (very low certainty).

1 finding from 1 review

Abrupt discontinuation deprescribing vs continued use

Lack of symptom control · people with mild to moderate esophagitis, symptomatic, aged > 18 years (mean age 73 years)

It is very uncertain whether abrupt discontinuation deprescribing changes lack of symptom control compared with continued use (very low certainty).

1 finding from 1 review

Abrupt discontinuation deprescribing vs continued use

Adverse drug withdrawal events ‐ relapse (endoscopic findings) · people with mild to moderate esophagitis, symptomatic, aged > 18 years (mean age 73 years)

It is very uncertain whether abrupt discontinuation deprescribing changes adverse drug withdrawal events ‐ relapse (endoscopic findings) compared with continued use (very low certainty).

1 finding from 1 review