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Evidence found and GRADE certainty

6 questions · 7 findings · 1 reviews · Schizophrenia

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 57.1%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

No clinically important response to treatment ‐ ultra short term (at 12 hours) · patients with schizophrenia

It is very uncertain whether ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS changes no clinically important response to treatment ‐ ultra short term (at… compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (very low certainty).

2 findings from 1 review

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

No clinically important response to treatment ‐ short term · patients with schizophrenia

It is very uncertain whether ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS changes no clinically important response to treatment ‐ short term (3 weeks… compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

Unacceptability of treatment (drop-outs / leaving study early) · patients with schizophrenia

It is very uncertain whether ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS changes leaving the study early due to any reason (overall acceptability of… compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

Adverse effects (drop‐outs due to adverse effects4) · patients with schizophrenia

It is very uncertain whether ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS changes leaving the study early due to adverse effects (overall tolerability… compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

Desired sedation ‐ ultra short term ‐ tranquillised at 60 minutes · patients with schizophrenia

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS may leads to higher desired sedation ‐ ultra short term ‐ tranquillised at 60 minutes compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (low certainty).

1 finding from 1 review

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

Desired sedation ‐ ultra short term ‐ asleep at 12 hours · patients with schizophrenia

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS showed no clear difference in desired sedation ‐ ultra short term ‐ asleep at 12 hours compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (low certainty).

1 finding from 1 review