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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
321 questions in 77 reviews · Dental caries
current versionsNo studies 321 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Partial pulpotomy vs Full (complete) pulpotomy Patient- and clinical-reported outcomes (tooth survival, clinical/radiographic success, pain) · Asymptomatic permanent teeth with deep caries (no symptoms) The effectiveness of partial pulpotomy compared with full pulpotomy in managing deep caries in vital… (2025) | no estimate extracted | 0 studies | No studies |
Cavity liner (calcium hydroxide, glass-ionomer cement, resin-modified calcium silicate/TheraCal LC, hydraulic calcium silicate/MTA or Biodentine, flowable composite, or other liner material) vs No cavity liner or a different liner material Oral health-related quality of life (OHRQoL) · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible… · >=6 months Efficacy of different cavity liners compared to no cavity lining in managing deep caries in vital permanent… (2025) | no estimate extracted | 0 studies | No studies |
quantitative light-induced fluorescence (QLF) vs reference standard detection of proximal caries · primary teeth with proximal caries · primary dentition Diagnostic accuracy of quantitative light-induced fluorescence in detecting caries of various types and… (2025) | no estimate extracted | 0 studies | No studies |
Intervention NR Tooth survival · - The effectiveness of partial pulpotomy compared with full pulpotomy in managing deep caries in vital… (2025) | no estimate extracted | 0 studies | No studies |
Pulp and periapical diseases vs Without pulp and periapical diseases Lacunar stroke · Adults The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian… (2025) | No studies addressing the association between pulp and periapical diseases and LS were identified. | 0 studies | No studies |
Microinvasive techniques (resin infiltration, sealant, glass ionomer) vs Invasive treatment (conventional restorations) Radiographic progression of proximal caries lesions · Children and adults with non-cavitated proximal (interproximal) caries lesions in primary and/or permanent teeth (ages… Microinvasive interventions in the management of proximal caries lesions in primary and permanent teeth-… (2025) | no estimate extracted | 0 studies | No studies |
Partial pulpotomy vs Full (complete) pulpotomy Oral health-related quality of life (OHRQoL) · Mature permanent (molar) teeth with deep caries and symptoms indicative of irreversible pulpitis (spontaneous pain) · >=6 months The effectiveness of partial pulpotomy compared with full pulpotomy in managing deep caries in vital… (2025) | no estimate extracted | 0 studies | No studies |
Dental caries vs Without dental caries Lacunar stroke · Adults The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian… (2025) | No studies addressing the association between dental caries and LS were identified. | 0 studies | No studies |
Partial pulpotomy vs Full (complete) pulpotomy Patient- and clinical-reported outcomes (tooth survival, clinical/radiographic success, pain) · Permanent teeth with deep caries and reversible pulpitis (non-spontaneous pain) The effectiveness of partial pulpotomy compared with full pulpotomy in managing deep caries in vital… (2025) | no estimate extracted | 0 studies | No studies |
High-intensity sweeteners other than stevia (aspartame, sucralose, saccharin) in food products vs Any comparator (dietary sugar, no treatment, or other sweetener) Effects of non-stevia high-intensity sweeteners (aspartame, sucralose, saccharin) on cariogenic bacteria in dental plaque or saliva · Generally healthy individuals across all age groups Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis. (2024) | No studies on high-intensity sweeteners such as sucralose, saccharin, or aspartame were found; the review located no eligible trials of these sweeteners on cariogenic bacteria. | 0 studies | No studies |
Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs Standard care dmfs index score · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | dmfs was listed in the SoF table but not assessed (not reported for this comparison). | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Glass ionomer cement (GIC) plus fluoride varnish Secondary prevention of caries · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Glass ionomer cement (GIC) plus fluoride varnish Dental pain or sensitivity · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Chlorhexidine varnish Secondary prevention of caries · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Oral health education/promotion (oral hygiene advice plus diet and feeding practice advice) combined with clinical treatment for mother's dentition (basic restorative and preventive; 1 trial included CHX varnish application) vs Standard care dmfs index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6… Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | dmfs was listed in the SoF table but not assessed (not reported for this comparison). | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Chlorhexidine varnish Caries arrest · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Sealants or resin infiltration Caries arrest · Children and adults (with or without carious lesions) · Primary and permanent dentition Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data in either dentition type | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Silver nitrate plus fluoride varnish Primary caries prevention · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution application in the dentition of women (mothers) vs Placebo dmft index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6… Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | dmft was listed in the SoF table but not assessed (no trial reported it). | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Glass ionomer cement (GIC) plus fluoride varnish Aesthetics · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Silver diamine fluoride (SDF) plus fluoride varnish vs Sealants plus fluoride varnish (with or without restorations) Aesthetics · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material Secondary prevention of caries · Children and adults (with or without carious lesions) · Primary and permanent dentition Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported this outcome | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Sealants or resin infiltration Aesthetics · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Sealants or resin infiltration Primary caries prevention · Children and adults (with or without carious lesions) · Permanent dentition (root) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data in this dentition type | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Sealants or resin infiltration Primary caries prevention · Children and adults (with or without carious lesions) · Primary dentition Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data in this dentition type | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Silver nitrate plus fluoride varnish Dental pain or sensitivity · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Breastfeeding promotion and support (e.g. individually tailored home-based peer counselling on the importance of breastfeeding, with advice and support for healthy breastfeeding) vs Standard care dmfs index score · For interventions, pregnant and lactating women; for outcomes, children up to 6 years of age Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | dmfs was listed in the SoF table but not assessed (not reported for this comparison). | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Placebo or no treatment Secondary prevention of caries · Children and adults (with or without carious lesions) · Permanent dentition (root) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies measured this outcome for root surfaces | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Fluoride varnish Secondary prevention of caries · Children and adults (with or without carious lesions) · Permanent dentition (root) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data in this dentition type | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material Primary caries prevention · Children and adults (with or without carious lesions) · Primary and permanent dentition Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported this outcome | 0 studies | No studies |
Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs Standard care dmft index score · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | dmft was listed in the SoF table but not assessed (not reported for this comparison). | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Glass ionomer cement (GIC) plus fluoride varnish Primary caries prevention · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Restoration (restorative treatment) Secondary prevention of caries · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Silver nitrate plus fluoride varnish Secondary prevention of caries · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Consumption of xylitol chewing gum by women (mothers) vs Consumption of CHX/xylitol gum by women, or CHX varnish applied to women's dentition dmfs index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6… Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | dmfs was listed in the SoF table but not assessed (not reported for this comparison). | 0 studies | No studies |
Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution application in the dentition of women (mothers) vs Placebo dmfs index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6… Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | dmfs was listed in the SoF table but not assessed (no trial reported it). | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Fluoride varnish Caries arrest · Children and adults (with or without carious lesions) · Permanent dentition (root) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data in this dentition type | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Fluoride varnish Caries arrest · Children and adults (with or without carious lesions) · Permanent dentition (coronal) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data in this dentition type | 0 studies | No studies |
Silver diamine fluoride (SDF) plus fluoride varnish vs Sealants plus fluoride varnish (with or without restorations) Dental pain or sensitivity · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Chlorhexidine varnish Aesthetics · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Chlorhexidine varnish Dental pain or sensitivity · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Atraumatic restorative treatment (ART) with glass ionomer cement (GIC) or glass ionomer material Caries arrest · Children and adults (with or without carious lesions) · Permanent dentition Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported this outcome in this dentition type | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Sealants or resin infiltration Dental pain or sensitivity · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome | 0 studies | No studies |
Silver diamine fluoride (SDF) plus fluoride varnish vs Sealants plus fluoride varnish (with or without restorations) Secondary prevention of caries · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Silver diamine fluoride (SDF) plus fluoride varnish vs Sealants plus fluoride varnish (with or without restorations) Primary caries prevention · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Health service and/or policy intervention designed to modify access to oral health information or services for pregnant women, new mothers or other primary caregivers vs Standard care (or any comparator) Outcome NR · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | No trials evaluated policy or health service interventions designed to modify access to oral health information or services. | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Restoration (restorative treatment) Primary caries prevention · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Placebo or no treatment Dental pain or sensitivity · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies measured this outcome | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Silver nitrate plus fluoride varnish Aesthetics · Children and adults (with or without carious lesions) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data for this outcome in this comparison | 0 studies | No studies |
Silver diamine fluoride (SDF) vs Fluoride varnish Secondary prevention of caries · Children and adults (with or without carious lesions) · Permanent dentition (coronal) Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane | No studies reported data in this dentition type | 0 studies | No studies |