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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

387 questions in 55 reviews · Common Mental Disorders

current versions
No studies 387 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Escitalopram vs placebo
Functional disability at 3 months ‐ not measured · adults experiencing acute traumatic stress symptoms
Early pharmacological interventions for prevention of post‐traumatic stress disorder (PTSD) in individuals… (2024) · Cochrane
no estimate extractedNRNo studies
Escitalopram vs placebo
Quality of life at 3 months ‐ not measured · adults experiencing acute traumatic stress symptoms
Early pharmacological interventions for prevention of post‐traumatic stress disorder (PTSD) in individuals… (2024) · Cochrane
no estimate extractedNRNo studies
Hydrocortisone vs placebo
Functional disability at 3 months ‐ not measured · adults experiencing acute traumatic stress symptoms
Early pharmacological interventions for prevention of post‐traumatic stress disorder (PTSD) in individuals… (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Psychosocial intervention vs control
Functioning at · promoting the mental health of people living in LMICs affected by humanitarian crises (adults)
Psychological and social interventions for the promotion of mental health in people living in low‐ and… (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Psychosocial intervention vs control
Prosocial behaviour at study endpoint ‐ not measured · promoting the mental health of people living in LMICs affected by humanitarian crises (adults)
Psychological and social interventions for the promotion of mental health in people living in low‐ and… (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Psychosocial intervention vs control
Prosocial behaviour at · promoting the mental health of people living in LMICs affected by humanitarian crises (adults)
Psychological and social interventions for the promotion of mental health in people living in low‐ and… (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Psychosocial intervention vs control
Functioning at study endpoint ‐ not measured · promoting the mental health of people living in LMICs affected by humanitarian crises (adults)
Psychological and social interventions for the promotion of mental health in people living in low‐ and… (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Mental Health First Aid (MHFA) training vs control
Mental health service usage ‐ not measured · improving mental health and wellbeing
Mental Health First Aid as a tool for improving mental health and well‐being (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Mental Health First Aid (MHFA) training vs control
Adverse effects of MHFA ‐ not measured · improving mental health and wellbeing
Mental Health First Aid as a tool for improving mental health and well‐being (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Mental Health First Aid (MHFA) training vs alternative mental health literacy interventions
Individual mental health ‐ not measured · improving mental health and wellbeing
Mental Health First Aid as a tool for improving mental health and well‐being (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Mental Health First Aid (MHFA) training vs alternative mental health literacy interventions
Mental health service usage ‐ not measured · improving mental health and wellbeing
Mental Health First Aid as a tool for improving mental health and well‐being (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Mental Health First Aid (MHFA) training vs alternative mental health literacy interventions
Adverse effects of MHFA ‐ not measured · improving mental health and wellbeing
Mental Health First Aid as a tool for improving mental health and well‐being (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Mental Health First Aid (MHFA) training vs alternative intervention
Individual mental health ‐ not measured · improving mental health and wellbeing
Mental Health First Aid as a tool for improving mental health and well‐being (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Mental Health First Aid (MHFA) training vs alternative intervention
Mental health service usage ‐ not measured · improving mental health and wellbeing
Mental Health First Aid as a tool for improving mental health and well‐being (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Mental Health First Aid (MHFA) training vs alternative intervention
Adverse effects of MHFA ‐ not measured · improving mental health and wellbeing
Mental Health First Aid as a tool for improving mental health and well‐being (2023) · Cochrane
no estimate extractedNRNo studies
Comparison 1: Alpha‐blockers vs placebo
Treatment efficacy ‐ treatment response, as measured by the Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults (aged 18‐85)
Pharmacotherapy for post traumatic stress disorder (PTSD) (2022) · Cochrane
no estimate extractedNRNo studies
Comparison 3: MAOIs vs placebo
Treatment efficacy ‐ treatment response, as measured by the Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults (aged 18‐85)
Pharmacotherapy for post traumatic stress disorder (PTSD) (2022) · Cochrane
no estimate extractedNRNo studies
Comparison 5: SNRIs vs placebo
Treatment efficacy ‐ treatment response, as measured by the Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults (aged 18‐85)
Pharmacotherapy for post traumatic stress disorder (PTSD) (2022) · Cochrane
no estimate extractedNRNo studies
Opioid antagonists vs placebo
Gambling expenditure ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Opioid antagonists vs placebo
Gambling frequency ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Opioid antagonists vs placebo
Time spent gambling ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Atypical antipsychotics vs placebo
Functional impairment ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Antidepressants vs opioid antagonists
Gambling expenditure ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Antidepressants vs opioid antagonists
Gambling frequency ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Antidepressants vs opioid antagonists
Time spent gambling ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Antidepressants vs opioid antagonists
Functional impairment ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Antidepressants vs mood stabilisers
Gambling expenditure ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Antidepressants vs mood stabilisers
Gambling frequency ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Antidepressants vs mood stabilisers
Time spent gambling ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Antidepressants vs mood stabilisers
Functional impairment ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Opioid antagonists vs mood stabilisers
Gambling symptom severity ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Opioid antagonists vs mood stabilisers
Gambling expenditure ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Opioid antagonists vs mood stabilisers
Gambling frequency ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Opioid antagonists vs mood stabilisers
Time spent gambling ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Opioid antagonists vs mood stabilisers
Functional impairment ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Opioid antagonists vs mood stabilisers
Responder status ‐ not measured · treatment of disordered and problem gambling
Pharmacological interventions for the treatment of disordered and problem gambling (2022) · Cochrane
no estimate extractedNRNo studies
Hydrocortisone vs placebo
PTSD severity at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event
Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) (2022) · Cochrane
no estimate extractedNRNo studies
Propranolol vs placebo
Quality of life at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event
Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) (2022) · Cochrane
no estimate extractedNRNo studies
Gabapentin vs placebo
Dropout due to adverse events at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event
Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) (2022) · Cochrane
no estimate extractedNRNo studies
Gabapentin vs placebo
Functional disability at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event
Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) (2022) · Cochrane
no estimate extractedNRNo studies
Gabapentin vs placebo
Quality of life at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event
Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) (2022) · Cochrane
no estimate extractedNRNo studies
Hydrocortisone vs placebo
Dropout due to adverse events at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event
Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) (2022) · Cochrane
no estimate extractedNRNo studies
Hydrocortisone vs placebo
PTSD rate at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event
Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) (2022) · Cochrane
no estimate extractedNRNo studies
Hydrocortisone vs placebo
Functional disability at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event
Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) (2022) · Cochrane
no estimate extractedNRNo studies
Hydrocortisone vs placebo
Quality of life at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event
Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) (2022) · Cochrane
no estimate extractedNRNo studies
Propranolol vs placebo
Dropout due to adverse events at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event
Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) (2022) · Cochrane
no estimate extractedNRNo studies
Propranolol vs placebo
Functional disability at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event
Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) (2022) · Cochrane
no estimate extractedNRNo studies
Antipsychotic vs placebo
Change in depression severity from baseline · adults with psychotic depression
Pharmacological treatment for psychotic depression (2021) · Cochrane
no estimate extractedNRNo studies
Antipsychotic vs placebo
Quality of life · adults with psychotic depression
Pharmacological treatment for psychotic depression (2021) · Cochrane
no estimate extractedNRNo studies
Antipsychotic vs placebo
Dropouts due to adverse effects · adults with psychotic depression
Pharmacological treatment for psychotic depression (2021) · Cochrane
no estimate extractedNRNo studies