What do systematic reviews say?

Quality of life · asymptomatic carotid stenosis

Outcomes (measurement/time point) · asymptomatic carotid stenosis

Quality of life, · individuals with moderate to severe disease

Clinical worsening: need for invasive mechanical ventilation, or death at up to day 28 · individuals with moderate to severe disease

Clinical improvement: participants discharged from hospital ‐ not reported · individuals with moderate to severe disease

Quality of life ‐ not reported · individuals with moderate to severe disease

Grades 3 and 4 adverse events ‐ not reported · individuals with moderate to severe disease

Serious adverse events ‐ not reported · individuals with moderate to severe disease

Resolution of symptoms · outpatients withmild disease

Quality of life, · outpatients withmild disease

Resolution of symptoms · outpatients withmild disease

Quality of life, · outpatients withmild disease

Grades 3 and 4 adverse events ‐ not reported · outpatients withmild disease

Serious adverse events ‐ not reported · outpatients withmild disease

Clinical improvement: participants discharged from hospital ‐ not reported · individuals with moderate to severe disease

Frequency of non‐hospitalised respiratory infection · people with CF

FEV1 % predicted: absolute change from baseline · people with CF

FVC (% predicted) Change from baseline · people with CF

QoL · people with CF

Exercise capacity (change from baseline) · people with CF