Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

15,213 questions in 2,394 reviews

current versions
No studies 15,213 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Direct resin composite veneer vs Indirect resin composite veneer
Colour match (aesthetic achievement) · Patients with permanent anterior teeth with intrinsic staining suitable for laminate veneer restorations
Direct versus indirect veneer restorations for intrinsic dental stains (2004) · Cochrane
Planned outcome; colour match was not reported by the single included trial (Meijering 1998).0 studiesNo studies
Ceramic inlays (all types) vs Composite resin inlay
Outcome NR · Adults who require restorative treatment in posterior teeth
Ceramic inlays for restoring posterior teeth (2003) · Cochrane
One randomised controlled trial (Gladys 1995) compared ceramic and resin composite inlays over 3 years, but it was excluded because the study design (parallel-group or split-mouth) was not clearly described; no…0 studiesNo studies
Ceramic inlays (all types) vs Amalgam
Outcome NR · Adults who require restorative treatment in posterior teeth
Ceramic inlays for restoring posterior teeth (2003) · Cochrane
No eligible randomised controlled trial comparing ceramic inlays with amalgam restorations was identified; this planned comparison could not be evaluated.0 studiesNo studies
Occlusal adjustment (OA) vs Placebo
Psychosocial outcomes · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD)
Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane
There were no data on psychosocial outcomes, costs or quality of life in any of the trials.0 studiesNo studies
Fluoride toothpaste vs Placebo (non-fluoride) toothpaste
Enamel fluorosis (adverse effect) · Children and adolescents aged 16 years or less · At least 1 year
Fluoride toothpastes for preventing dental caries in children and adolescents (2003) · Cochrane
Fluorosis data have not been reported in any of the trials.0 studiesNo studies
Ceramic inlays (all types) vs Gold inlay
Aesthetic satisfaction (colour match) · Adults who require restorative treatment in posterior teeth
Ceramic inlays for restoring posterior teeth (2003) · Cochrane
Information on aesthetic satisfaction could not be obtained from this study as it did not use the tooth-coloured restorations as the control group.0 studiesNo studies
Occlusal adjustment (OA) vs Placebo
Quality of life · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD)
Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane
There were no data on psychosocial outcomes, costs or quality of life in any of the trials.0 studiesNo studies
Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs Placebo or no treatment
Dental fluorosis · Children and adolescents aged 16 years or younger
Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and… (2003) · Cochrane
Fluorosis data have not been reported in any of the trials.0 studiesNo studies
Occlusal adjustment (OA) vs Placebo
Adverse events · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD)
Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane
There were no reports of adverse reactions.0 studiesNo studies
Occlusal adjustment (OA) vs Placebo
Cost · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD)
Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane
There were no data on psychosocial outcomes, costs or quality of life in any of the trials.0 studiesNo studies
Ceramic inlays (all types) vs Composite resin (direct restoration)
Outcome NR · Adults who require restorative treatment in posterior teeth
Ceramic inlays for restoring posterior teeth (2003) · Cochrane
No eligible randomised controlled trial comparing ceramic inlays with composite resin (direct) restorations was identified; this planned comparison could not be evaluated.0 studiesNo studies
Summary of findings: leflunomide vs placebo, 6 months
For outcome · adult patients with rheumatoid arthritis
Leflunomide for the treatment of rheumatoid arthritis (2002) · Cochrane
no estimate extractedNRNo studies
Summary of findings: leflunomide + methotrexate vs methotrexate, 6 months
For outcome · adult patients with rheumatoid arthritis
Leflunomide for the treatment of rheumatoid arthritis (2002) · Cochrane
no estimate extractedNRNo studies