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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
387 questions in 55 reviews · Common Mental Disorders
current versionsNo studies 387 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Ketamine vs placebo Acceptability: dropouts due to adverse effects ‐ not reported · adults (aged 18 years+) with unipolar major depressive disorder Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive… (2021) · Cochrane | no estimate extracted | NR | No studies |
Internet‐based cognitive and behavioural therapy (I‐C/BT) vs wait list Cost‐effectiveness · adults aged ≥ 16 years with PTSD Internet‐based cognitive and behavioural therapies for post‐traumatic stress disorder (PTSD) in adults (2021) · Cochrane | no estimate extracted | NR | No studies |
Internet‐based cognitive and behavioural therapy (I‐C/BT) vs I‐non‐C/BT Diagnosis of PTSD after treatment · adults aged ≥ 16 years with PTSD Internet‐based cognitive and behavioural therapies for post‐traumatic stress disorder (PTSD) in adults (2021) · Cochrane | no estimate extracted | NR | No studies |
Internet‐based cognitive and behavioural therapy (I‐C/BT) vs I‐non‐C/BT Cost‐effectiveness · adults aged ≥ 16 years with PTSD Internet‐based cognitive and behavioural therapies for post‐traumatic stress disorder (PTSD) in adults (2021) · Cochrane | no estimate extracted | NR | No studies |
Internet‐based cognitive and behavioural therapy (I‐C/BT) vs face‐to‐face non‐CBT Diagnosis of PTSD after treatment · adults aged ≥ 16 years with PTSD Internet‐based cognitive and behavioural therapies for post‐traumatic stress disorder (PTSD) in adults (2021) · Cochrane | no estimate extracted | NR | No studies |
Internet‐based cognitive and behavioural therapy (I‐C/BT) vs face‐to‐face non‐CBT Severity of depressive symptoms ( · adults aged ≥ 16 years with PTSD Internet‐based cognitive and behavioural therapies for post‐traumatic stress disorder (PTSD) in adults (2021) · Cochrane | no estimate extracted | NR | No studies |
Internet‐based cognitive and behavioural therapy (I‐C/BT) vs face‐to‐face non‐CBT Severity of anxiety symptoms ( · adults aged ≥ 16 years with PTSD Internet‐based cognitive and behavioural therapies for post‐traumatic stress disorder (PTSD) in adults (2021) · Cochrane | no estimate extracted | NR | No studies |
Internet‐based cognitive and behavioural therapy (I‐C/BT) vs face‐to‐face non‐CBT Cost‐effectiveness · adults aged ≥ 16 years with PTSD Internet‐based cognitive and behavioural therapies for post‐traumatic stress disorder (PTSD) in adults (2021) · Cochrane | no estimate extracted | NR | No studies |
Internet‐based cognitive and behavioural therapy (I‐C/BT) vs face‐to‐face non‐CBT Adverse events · adults aged ≥ 16 years with PTSD Internet‐based cognitive and behavioural therapies for post‐traumatic stress disorder (PTSD) in adults (2021) · Cochrane | no estimate extracted | NR | No studies |
Cognitive behavioural therapy vs anxiety management Outcomes · obsessive compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD) Behavioural and cognitive behavioural therapy for obsessive compulsive disorder (OCD) in individuals with… (2021) · Cochrane | no estimate extracted | NR | No studies |
Cognitive behavioural therapy vs anxiety management Behavioural difficulties, end of treatment · obsessive compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD) Behavioural and cognitive behavioural therapy for obsessive compulsive disorder (OCD) in individuals with… (2021) · Cochrane | no estimate extracted | NR | No studies |
Melatonin vs placebo Diabetes · Adults with mental disorders in low‐ and middle‐income countries Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income… (2021) · Cochrane | no estimate extracted | NR | No studies |
SSRI antidepressants vs TCA Diabetes · Adults with mental disorders in low‐ and middle‐income countries Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income… (2021) · Cochrane | no estimate extracted | NR | No studies |
Metformin vs placebo Diabetes · Adults with mental disorders in low‐ and middle‐income countries Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income… (2021) · Cochrane | no estimate extracted | NR | No studies |
Abrupt discontinuation vs continuation of long‐term antidepressants Successful discontinuation rate · participants with depressive or anxiety disorders Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and… (2021) · Cochrane | no estimate extracted | NR | No studies |
Discontinuation with high‐intensity psychological interventions vs continuation Withdrawal symptoms · participants with long‐term antidepressants for depressive disorders Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and… (2021) · Cochrane | no estimate extracted | NR | No studies |
Discontinuation with high‐intensity psychological interventions vs continuation Anxiety symptoms · participants with long‐term antidepressants for depressive disorders Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and… (2021) · Cochrane | no estimate extracted | NR | No studies |
Discontinuation with high‐intensity psychological interventions vs continuation Social and occupational functioning · participants with long‐term antidepressants for depressive disorders Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and… (2021) · Cochrane | no estimate extracted | NR | No studies |
Discontinuation of long‐term antidepressant with minimal intervention vs usual care Withdrawal symptoms · participants with long‐term antidepressants for depressive or anxiety disorders Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and… (2021) · Cochrane | no estimate extracted | NR | No studies |
Discontinuation of long‐term antidepressant with minimal intervention vs usual care Adverse events · participants with long‐term antidepressants for depressive or anxiety disorders Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and… (2021) · Cochrane | no estimate extracted | NR | No studies |
Discontinuation of long‐term antidepressant with minimal intervention vs usual care Social and occupational functioning · participants with long‐term antidepressants for depressive or anxiety disorders Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and… (2021) · Cochrane | no estimate extracted | NR | No studies |
Abrupt discontinuation vs continuation of long‐term antidepressants Quality of life · participants with depressive or anxiety disorders Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and… (2021) · Cochrane | no estimate extracted | NR | No studies |
Abrupt discontinuation vs continuation of long‐term antidepressants Social and occupational functioning · participants with depressive or anxiety disorders Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and… (2021) · Cochrane | no estimate extracted | NR | No studies |
Discontinuation by "tapering" vs continuation (or usual care) Successful discontinuation rate Studies without co‐intervention · participants with depressive or anxiety disorders Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and… (2021) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR MST vs ECT ‐ suicides, suicide attempts, self‐harm · patients with schizophrenia Magnetic seizure therapy for treatment‐resistant depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR MST vs ECT ‐ social functioning · patients with schizophrenia Magnetic seizure therapy for treatment‐resistant depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR MST vs ECT ‐ serious adverse events · patients with schizophrenia Magnetic seizure therapy for treatment‐resistant depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressants vs treatment Child‐related outcomes · women of any age, with PND up to 12 months Antidepressant treatment for postnatal depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressants vs psychological interventions Depression response or remission (acute phase, 5 ≤ 12 weeks) · women of any age, with PND up to 12 months Antidepressant treatment for postnatal depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressants vs psychological interventions Child‐related outcomes · women of any age, with PND up to 12 months Antidepressant treatment for postnatal depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressants vs psychosocial interventions Depression response or remission (acute phase, 5 ≤ 12 weeks) · women of any age, with PND up to 12 months Antidepressant treatment for postnatal depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressants vs psychosocial interventions Adverse events · women of any age, with PND up to 12 months Antidepressant treatment for postnatal depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressants vs psychosocial interventions Depression severity (acute phase, 5 ≤ 12 weeks) · women of any age, with PND up to 12 months Antidepressant treatment for postnatal depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressants vs psychosocial interventions Child‐related outcomes · women of any age, with PND up to 12 months Antidepressant treatment for postnatal depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressants vs any other pharmacological intervention Adverse events · women of any age, with PND up to 12 months Antidepressant treatment for postnatal depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressants vs any other pharmacological intervention Child‐related outcomes · women of any age, with PND up to 12 months Antidepressant treatment for postnatal depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressants vs any complementary medicine Adverse events · women of any age, with PND up to 12 months Antidepressant treatment for postnatal depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressants vs any complementary medicine Depression severity · women of any age, with PND up to 12 months Antidepressant treatment for postnatal depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressants vs any complementary medicine Treatment acceptability · women of any age, with PND up to 12 months Antidepressant treatment for postnatal depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressants vs any complementary medicine Child‐related outcomes · women of any age, with PND up to 12 months Antidepressant treatment for postnatal depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressants vs placebo Child‐related outcomes · women of any age, with PND up to 12 months Antidepressant treatment for postnatal depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressants vs treatment Depression response or remission (acute, 5 ≤ 12 weeks) · women of any age, with PND up to 12 months Antidepressant treatment for postnatal depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Mindfulness vs no treatment or waiting list  Mindfulness‐based psychological interventions for improving mental well‐being in medical students and junior… (2021) · Cochrane | no estimate extracted | NR | No studies |
Mindfulness vs no treatment or waiting list Suicidal ideation Mindfulness‐based psychological interventions for improving mental well‐being in medical students and junior… (2021) · Cochrane | no estimate extracted | NR | No studies |
Mindfulness vs no treatment or waiting list Suicidal behaviour Mindfulness‐based psychological interventions for improving mental well‐being in medical students and junior… (2021) · Cochrane | no estimate extracted | NR | No studies |
Mindfulness vs no treatment or waiting list Deliberate self‐harm Mindfulness‐based psychological interventions for improving mental well‐being in medical students and junior… (2021) · Cochrane | no estimate extracted | NR | No studies |
Hypnosis vs wait list Level of functioning · people with conversion disorder according to DSM‐IV or ICD‐10 criteria Psychosocial interventions for conversion and dissociative disorders in adults (2020) · Cochrane | no estimate extracted | NR | No studies |
Hypnosis vs wait list Quality of life · people with conversion disorder according to DSM‐IV or ICD‐10 criteria Psychosocial interventions for conversion and dissociative disorders in adults (2020) · Cochrane | no estimate extracted | NR | No studies |
Hypnosis vs wait list Adverse events · people with conversion disorder according to DSM‐IV or ICD‐10 criteria Psychosocial interventions for conversion and dissociative disorders in adults (2020) · Cochrane | no estimate extracted | NR | No studies |
Behavioural therapy plus treatment as usual vs treatment Level of functioning · people with conversion disorder according to DSM‐IV or ICD‐10 criteria Psychosocial interventions for conversion and dissociative disorders in adults (2020) · Cochrane | no estimate extracted | NR | No studies |