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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
190 questions in 24 reviews · Epilepsy
current versionsNo studies 190 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intermittent oral ibuprofen vs placebo Recurrent seizure at 60 months or greater · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral clobazam vs placebo Recurrent seizure at 12 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral clobazam vs placebo Recurrent seizure at 18 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral clobazam vs placebo Recurrent seizure at 24 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral clobazam vs placebo Recurrent seizure at 36 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral clobazam vs placebo Recurrent seizure at 48 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral clobazam vs placebo Recurrent seizure at 60 months or greater · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous zinc sulfate for 6 months vs placebo Recurrent seizure at 6 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous zinc sulfate for 6 months vs placebo Recurrent seizure at 18 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous zinc sulfate for 6 months vs placebo Recurrent seizure at 24 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous zinc sulfate for 6 months vs placebo Recurrent seizure at 36 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous zinc sulfate for 6 months vs placebo Recurrent seizure at 48 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous zinc sulfate for 6 months vs placebo Recurrent seizure at 60 months or greater · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent rectal diclofenac vs placebo, followed by oral ibuprofen, paracetamol, or placebo after 8 hours, Recurrent seizure at 36 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent rectal diclofenac vs placebo, followed by oral ibuprofen, paracetamol, or placebo after 8 hours, Recurrent seizure at 48 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent rectal diclofenac vs placebo, followed by oral ibuprofen, paracetamol, or placebo after 8 hours, Recurrent seizure at 60 months or greater · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous phenobarbital vs intermittent rectal or oral diazepam Recurrent seizure at 6 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous phenobarbital vs intermittent rectal or oral diazepam Recurrent seizure at 24 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous phenobarbital vs intermittent rectal or oral diazepam Recurrent seizure at 36 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous phenobarbital vs intermittent rectal or oral diazepam Recurrent seizure at 48 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Continuous phenobarbital vs intermittent rectal or oral diazepam Recurrent seizure at 60 months or greater · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent rectal diazepam vs intermittent rectal valproate Recurrent seizure at 18 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent rectal diazepam vs intermittent rectal valproate Recurrent seizure at 24 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent rectal diazepam vs intermittent rectal valproate Recurrent seizure at 36 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent rectal diazepam vs intermittent rectal valproate Recurrent seizure at 48 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent rectal diazepam vs intermittent rectal valproate Recurrent seizure at 60 months or greater · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral diazepam vs intermittent oral clobazam Recurrent seizure at 6 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral diazepam vs intermittent oral clobazam Recurrent seizure at 18 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral diazepam vs intermittent oral clobazam Recurrent seizure at 24 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral diazepam vs intermittent oral clobazam Recurrent seizure at 36 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral diazepam vs intermittent oral clobazam Recurrent seizure at 48 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral diazepam vs intermittent oral clobazam Recurrent seizure at 60 months or greater · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral melatonin vs intermittent oral diazepam Recurrent seizures at 12 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral melatonin vs intermittent oral diazepam Recurrent seizures at 18 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral melatonin vs intermittent oral diazepam Recurrent seizures at 24 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral melatonin vs intermittent oral diazepam Recurrent seizures at 36 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral melatonin vs intermittent oral diazepam Recurrent seizures at 48 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral melatonin vs intermittent oral diazepam Recurrent seizures at 60 months or greater · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Intermittent oral levetiracetam vs placebo (any antipyretics) Recurrent seizures at 6 months · children with febrile seizures Prophylactic drug management for febrile seizures in children (2021) · Cochrane | no estimate extracted | NR | No studies |
Ethosuximide vs lamotrigine 80% or greater reduction in seizure frequency ‐ not reported · absence seizures in children and adolescents Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents (2021) · Cochrane | no estimate extracted | NR | No studies |
Ethosuximide vs lamotrigine 50% or greater reduction in seizure frequency ‐ not reported · absence seizures in children and adolescents Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents (2021) · Cochrane | no estimate extracted | NR | No studies |
Ethosuximide vs lamotrigine Normalisation of the EEG ‐ not reported · absence seizures in children and adolescents Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents (2021) · Cochrane | no estimate extracted | NR | No studies |
Ethosuximide vs valproate Normalisation of the EEG ‐ not reported · absence seizures in children and adolescents Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents (2021) · Cochrane | no estimate extracted | NR | No studies |
Lamotrigine vs valproate 80% or greater reduction in seizure frequency ‐ not reported · absence seizures in children and adolescents Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents (2021) · Cochrane | no estimate extracted | NR | No studies |
Lamotrigine vs valproate 50% or greater reduction in seizure frequency ‐ not reported · absence seizures in children and adolescents Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents (2021) · Cochrane | no estimate extracted | NR | No studies |
Cannabidiol (10 mg/kg and 20 mg/kg) plus ASMs vs placebo plus ASMs Number of participants free from all seizures · Lennox‐Gastaut syndrome, any age Anti‐seizure medications for Lennox‐Gastaut syndrome (2021) · Cochrane | no estimate extracted | NR | No studies |
Clobazam (low, medium and high doses) plus ASMs vs placebo plus ASMs Number of participants with ≥ 75% reduction in all seizures · Lennox‐Gastaut syndrome, any age Anti‐seizure medications for Lennox‐Gastaut syndrome (2021) · Cochrane | no estimate extracted | NR | No studies |
Clobazam (low, medium and high doses) plus ASMs vs placebo plus ASMs Number of participants with ≥ 50% reduction in all seizures · Lennox‐Gastaut syndrome, any age Anti‐seizure medications for Lennox‐Gastaut syndrome (2021) · Cochrane | no estimate extracted | NR | No studies |
Felbamate plus ASMs vs placebo plus ASMs Number of participants with ≥ 75% reduction in all seizures · Lennox‐Gastaut syndrome, any age Anti‐seizure medications for Lennox‐Gastaut syndrome (2021) · Cochrane | no estimate extracted | NR | No studies |
Felbamate plus ASMs vs placebo plus ASMs Number of participants with ≥ 50% reduction in all seizures · Lennox‐Gastaut syndrome, any age Anti‐seizure medications for Lennox‐Gastaut syndrome (2021) · Cochrane | no estimate extracted | NR | No studies |