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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
387 questions in 55 reviews · Common Mental Disorders
current versionsNo studies 387 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Antidepressant vs antidepressant Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs antidepressant Change in depression severity from baseline · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs antidepressant Quality of life · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs antidepressant Dropouts due to adverse effects · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs antipsychotic Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs antipsychotic Change in depression severity from baseline · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs antipsychotic Quality of life · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs antipsychotic Dropouts due to adverse effects · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo Change in depression severity from baseline · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo Quality of life · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs placebo Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo Dropouts due to adverse effects · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antipsychotic Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antipsychotic Change in depression severity from baseline · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antipsychotic Quality of life · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antipsychotic Dropouts due to adverse effects · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antidepressant Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs placebo Change in depression severity from baseline · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antidepressant Change in depression severity from baseline · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antidepressant Quality of life · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antidepressant Dropouts due to adverse effects · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus the same antidepressant Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus the same antidepressant Change in depression severity from baseline · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus the same antidepressant Quality of life · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus the same antidepressant Dropouts due to adverse effects · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs placebo Quality of life · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs placebo Dropouts due to adverse effects · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antipsychotic vs placebo Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Opioid antagonists vs placebo Tolerability of treatment ‐ dropouts due to adverse events · adults with trichotillomania Pharmacotherapy for trichotillomania (2021) · Cochrane | no estimate extracted | NR | No studies |
SSRIs vs placebo Treatment response · adults with trichotillomania Pharmacotherapy for trichotillomania (2021) · Cochrane | no estimate extracted | NR | No studies |
Fluoxetine vs light therapy Time to onset of response · adults with seasonal affective disorder Second‐generation antidepressants for treatment of seasonal affective disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
Fluoxetine vs placebo Clinical Global Impression – Improvement score · adults with seasonal affective disorder Second‐generation antidepressants for treatment of seasonal affective disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
Fluoxetine vs placebo Quality of life · adults with seasonal affective disorder Second‐generation antidepressants for treatment of seasonal affective disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
Fluoxetine vs placebo Remission · adults with seasonal affective disorder Second‐generation antidepressants for treatment of seasonal affective disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
Fluoxetine vs placebo Speed of onset of response · adults with seasonal affective disorder Second‐generation antidepressants for treatment of seasonal affective disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
Fluoxetine vs light therapy Clinical Global Impression – Improvement score · adults with seasonal affective disorder Second‐generation antidepressants for treatment of seasonal affective disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
Cytidine vs placebo Efficacy: number of participants who achieve remission · adults (aged 18 years+) with depression in bipolar disorder Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
Cytidine vs placebo Depression rating scale score · adults (aged 18 years+) with depression in bipolar disorder Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
Cytidine vs placebo Acceptability: dropouts due to adverse effects · adults (aged 18 years+) with depression in bipolar disorder Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
N‐acetylcysteine vs placebo Efficacy: number of participants who achieve remission ‐ not reported · adults (aged 18 years+) with depression in bipolar disorder Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
N‐acetylcysteine vs placebo Acceptability: total dropouts ‐ not reported · adults (aged 18 years+) with depression in bipolar disorder Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
N‐acetylcysteine vs placebo Acceptability: dropouts due to adverse effects ‐ not reported · adults (aged 18 years+) with depression in bipolar disorder Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
Riluzole vs placebo Efficacy: number of participants who respond to treatment ‐ not reported · Adults (aged 18 years+) with depression in bipolar disorder Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
Riluzole vs placebo Efficacy: number of participants who achieve remission ‐ not reported · Adults (aged 18 years+) with depression in bipolar disorder Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
Riluzole vs placebo Depression rating scale scores ‐ not reported · Adults (aged 18 years+) with depression in bipolar disorder Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
Riluzole vs placebo Acceptability: dropouts due to adverse effects ‐ not reported · Adults (aged 18 years+) with depression in bipolar disorder Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
Ketamine vs placebo Acceptability: dropouts due to adverse effects · adults (aged 18 years+) with depression in bipolar disorder Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder (2021) · Cochrane | no estimate extracted | NR | No studies |
Ketamine vs midazolam Acceptability: dropouts due to adverse effects ‐ not reported · adults (aged 18 years+) with unipolar major depressive disorder Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive… (2021) · Cochrane | no estimate extracted | NR | No studies |
Esketamine vs placebo Acceptability: dropouts due to adverse effects ‐ not reported · adults (aged 18 years+) with unipolar major depressive disorder Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive… (2021) · Cochrane | no estimate extracted | NR | No studies |