Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

15,213 questions in 2,394 reviews

current versions
No studies 15,213 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Four‐food elimination diet with omeprazole vs omeprazole
Endoscopic improvement at study endpoint (continuous) · active EoE patients
Medical treatment of eosinophilic esophagitis (2023) · Cochrane
no estimate extractedNRNo studies
Four‐food elimination and amino acid formula vs four‐food elimination diet
Clinical improvement (dichotomous) · active EoE patients
Medical treatment of eosinophilic esophagitis (2023) · Cochrane
no estimate extractedNRNo studies
Four‐food elimination and amino acid formula vs four‐food elimination diet
Endoscopic improvement (dichotomous) · active EoE patients
Medical treatment of eosinophilic esophagitis (2023) · Cochrane
no estimate extractedNRNo studies
Nebulized budesonide vs viscous budesonide
Clinical improvement (dichotomous) · active EoE patients
Medical treatment of eosinophilic esophagitis (2023) · Cochrane
no estimate extractedNRNo studies
Nebulized budesonide vs viscous budesonide
Histological improvement at 8 weeks (dichotomous) · active EoE patients
Medical treatment of eosinophilic esophagitis (2023) · Cochrane
no estimate extractedNRNo studies
Nebulized budesonide vs viscous budesonide
Endoscopic improvement (continuous) · active EoE patients
Medical treatment of eosinophilic esophagitis (2023) · Cochrane
no estimate extractedNRNo studies
Viaskin milk patch vs placebo
Clinical improvement (dichotomous) · active EoE pediatric patients
Medical treatment of eosinophilic esophagitis (2023) · Cochrane
no estimate extractedNRNo studies
Viaskin milk patch vs placebo
Histological improvement (dichotomous) · active EoE pediatric patients
Medical treatment of eosinophilic esophagitis (2023) · Cochrane
no estimate extractedNRNo studies
Viaskin milk patch vs placebo
Endoscopic improvement (dichotomous) · active EoE pediatric patients
Medical treatment of eosinophilic esophagitis (2023) · Cochrane
no estimate extractedNRNo studies
Cycled inhaled tobramycin (TNS) vs culture‐based TNS
Eradication of P aeruginosa from the respiratory tract: proportion of participants with one or more isolates of P aeruginosa from the respiratory tract · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Cycled inhaled tobramycin (TNS) vs culture‐based TNS
FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy
Eradication of P aeruginosa from the respiratory tract: proportion of participants with one or more isolates of P aeruginosa from the respiratory tract · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy
FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS)
FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS)
Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Inhaled colistin plus oral ciprofloxacin vs inhaled tobramycin (TNS) plus oral ciprofloxacin
FEV1: relative change in % predicted FEV1 from baseline · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Inhaled colistin plus oral ciprofloxacin vs inhaled tobramycin (TNS) plus oral ciprofloxacin
FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Inhaled colistin plus oral ciprofloxacin vs inhaled tobramycin (TNS) plus oral ciprofloxacin
Growth and nutritional status · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Inhaled tobramycin (TNS) vs placebo
Growth and nutritional status: change in weight (kg) from baseline · adults and children with cystic fibrosis and a positive microbiological isolate of Pseudomonas aeruginosa from a…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Inhaled colistin plus oral ciprofloxacin vs inhaled tobramycin (TNS) plus oral ciprofloxacin
Frequency of infective pulmonary exacerbations: number of exacerbations per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Inhaled tobramycin (TNS) vs placebo
Frequency of infective pulmonary exacerbations: number of exacerbations per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of Pseudomonas aeruginosa from a…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Oral ciprofloxacin and inhaled colistin vs no treatment
Eradication of P aeruginosa from the respiratory tract · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Oral ciprofloxacin and inhaled colistin vs no treatment
FEV1 · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Oral ciprofloxacin and inhaled colistin vs no treatment
FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Oral ciprofloxacin and inhaled colistin vs no treatment
Growth and nutritional status · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Oral ciprofloxacin and inhaled colistin vs no treatment
Frequency of infective pulmonary exacerbations: number of exacerbations per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Oral ciprofloxacin and inhaled colistin vs no treatment
Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI
FEV1 % predicted · children and adolescents with cystic fibrosis
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI
FVC % predicted · children and adolescents with cystic fibrosis
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Inhaled tobramycin (TNS) vs placebo
Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of Pseudomonas aeruginosa from a…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI
Growth and nutritional status · children and adolescents with cystic fibrosis
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI
Frequency of infective pulmonary exacerbations · children and adolescents with cystic fibrosis
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI
Isolation of other micro‐organisms from the respiratory tract · children and adolescents with cystic fibrosis
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI
Adverse effects of antibiotics: number of participants reporting a serious adverse event · children and adolescents with cystic fibrosis
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Intravenous ceftazidime with tobramycin vs oral ciprofloxacin
Eradication of P aeruginosa from the respiratory tract: number of participants testing negative for P aeruginosa at 3 months and remaining free until 15 months · adults and children with cystic fibrosis and a positive microbiological isolate of Pseudomonas aeruginosa from a…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Inhaled tobramycin (TNS) (28 days) vs TNS (56 days)
Eradication of P aeruginosa from the respiratory tract: time to next isolation of P aeruginosa from BAL, sputum or oropharyngeal cultures · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory…
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane
no estimate extractedNRNo studies
Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin
Severe intraventricular haemorrhage · neonates with sepsis
Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates (2023) · Cochrane
no estimate extractedNRNo studies
Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin
Periventricular leukomalacia · neonates with sepsis
Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates (2023) · Cochrane
no estimate extractedNRNo studies
Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin
Length of hospital stay in days for survivors to discharge · neonates with sepsis
Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates (2023) · Cochrane
no estimate extractedNRNo studies
Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin
Retinopathy of prematurity, any stage · neonates with sepsis
Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates (2023) · Cochrane
no estimate extractedNRNo studies
Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics
Chronic lung diseasein survivors · neonates with sepsis
Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates (2023) · Cochrane
no estimate extractedNRNo studies
Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics
Severe intraventricular haemorrhage · neonates with sepsis
Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates (2023) · Cochrane
no estimate extractedNRNo studies
Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics
Periventricular leukomalacia · neonates with sepsis
Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates (2023) · Cochrane
no estimate extractedNRNo studies
Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics
Length of hospital stay in days for survivors to discharge · neonates with sepsis
Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates (2023) · Cochrane
no estimate extractedNRNo studies
Pentoxifylline with antibiotics (any dose or duration) vs immunoglobulin M‐enriched intravenous immunoglobulin with antibiotics
Retinopathy of prematurity, any stage · neonates with sepsis
Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates (2023) · Cochrane
no estimate extractedNRNo studies
Pentoxifylline with antibiotics (any dose or duration) vs pentoxifylline with antibiotics and immunoglobulin M‐enriched intravenous immunoglobulin
Chronic lung disease in survivors · neonates with sepsis
Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates (2023) · Cochrane
no estimate extractedNRNo studies
Surgery vs botulinum neurotoxin injections
Presence and quality of binocularity at 6 months · children with infantile esotropia
Interventions for infantile esotropia (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings ‐ Supplemental breast milk vs control
Any adverse outcome · term newborns (≥ 37 completed weeks' postmenstrual age) and preterm infants (< 37 completed weeks' postmenstrual age)…
Breastfeeding or breast milk for procedural pain in neonates (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings ‐ Breastfeeding vs control
Any adverse outcome · term newborns (≥ 37 completed weeks' postmenstrual age) and preterm infants (< 37 completed weeks' postmenstrual age)…
Breastfeeding or breast milk for procedural pain in neonates (2023) · Cochrane
no estimate extractedNRNo studies
Low glycaemic index (GI) or low glycaemic load (GL) diets vs any other diet
All‐cause mortality · people with obesity or overweight
Low glycaemic index or low glycaemic load diets for people with overweight or obesity (2023) · Cochrane
no estimate extractedNRNo studies