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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,344 questions in 217 reviews · Oral Health
current versionsNo studies 1,344 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mineral trioxide aggregate (MTA) vs Gutta-percha / AH-Plus Outcome NR · Children with extensive decay involving the dental pulp in primary teeth Pulp treatment for extensive decay in primary teeth (2018) · Cochrane | Listed as a pulpectomy comparison; no extractable outcome data reported in this version | 0 studies | No studies |
Orthodontic treatment without extraction of permanent teeth (removable, fixed, or functional braces, or headgear) vs No treatment (or delayed treatment) Cephalometric measurements (ANB change and front teeth inclination changes) · Children (80% aged <= 16 years) with a Class II division 2 malocclusion (deep bite and retroclined upper front teeth) Orthodontic treatment for deep bite and retroclined upper front teeth in children (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine Duration of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario… Injectable local anaesthetic agents for dental anaesthesia (2018) · Cochrane | SoF: Not measured. | 0 studies | No studies |
Wax (fluid wax), two stage-two step selective pressure final impression vs Polysulfide rubber (elastomer) Participant-reported oral health-related quality of life (OHIP-EDENT) · Completely edentulous people Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | Not measured | 0 studies | No studies |
Slow-release fluoride devices vs Alternative fluoride therapy (topical fluoride: toothpaste, mouthrinse, gel, or varnish) Outcome NR · Children or adults Slow‐release fluoride devices for the control of dental decay (2018) · Cochrane | We found no studies comparing a slow-release fluoride device versus alternative fluoride therapy | 0 studies | No studies |
Wax (fluid wax), two stage-two step selective pressure final impression vs Polysulfide rubber (elastomer) Participant-reported quality of the denture · Completely edentulous people Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | Not measured | 0 studies | No studies |
3% prilocaine, 0.03 IU felypressin vs 2% lidocaine, 1:100,000 epinephrine Adverse effects: pain on injection (solution deposition) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario… Injectable local anaesthetic agents for dental anaesthesia (2018) · Cochrane | SoF: Not measured. | 0 studies | No studies |
4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine Speed of onset of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario… Injectable local anaesthetic agents for dental anaesthesia (2018) · Cochrane | SoF: Not measured. | 0 studies | No studies |
Zinc oxide and eugenol (ZOE) vs Ozonated sesame oil-zinc oxide (ZO) Outcome NR · Children with extensive decay involving the dental pulp in primary teeth Pulp treatment for extensive decay in primary teeth (2018) · Cochrane | Listed as a pulpectomy comparison; no extractable outcome data reported in this version | 0 studies | No studies |
SPT provided at one time interval vs SPT provided at a different time interval Outcome NR · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT) Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo (placebo solution/mouthwash) Bleeding duration (minutes, all types of bleeding, minor and major) · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and… Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral… (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
Supportive periodontal therapy (SPT) including mechanical debridement vs Monitoring only, or alternative interventions that do not include mechanical debridement Outcome NR · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT) Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
Autologous platelet concentrates (APC) + guided tissue regeneration (GTR) vs GTR (guided tissue regeneration) alone Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane | No quantitative analysis regarding patients' quality of life was possible (no data). | 0 studies | No studies |
Orthodontic treatment without extraction of permanent teeth vs Orthodontic treatment involving extraction of permanent teeth Side effects · Children (80% aged <= 16 years) with a Class II division 2 malocclusion (deep bite and retroclined upper front teeth) Orthodontic treatment for deep bite and retroclined upper front teeth in children (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
Routine scale and polish provided by a dentist vs Routine scale and polish provided by a dental care professional (dental therapist or hygienist) Probing depth · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental… Routine scale and polish for periodontal health in adults (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine Adverse effects: allergy to local anaesthetic · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario… Injectable local anaesthetic agents for dental anaesthesia (2018) · Cochrane | SoF: Not measured. | 0 studies | No studies |
4% articaine, 1:200,000 epinephrine vs 4% articaine, 1:100,000 epinephrine Duration of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario… Injectable local anaesthetic agents for dental anaesthesia (2018) · Cochrane | SoF: Not measured. | 0 studies | No studies |
4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine Adverse effects: paraesthesia following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario… Injectable local anaesthetic agents for dental anaesthesia (2018) · Cochrane | SoF: Not measured. | 0 studies | No studies |
Orthodontic treatment without extraction of permanent teeth vs Orthodontic treatment involving extraction of permanent teeth Cephalometric measurements (ANB change and front teeth inclination changes) · Children (80% aged <= 16 years) with a Class II division 2 malocclusion (deep bite and retroclined upper front teeth) Orthodontic treatment for deep bite and retroclined upper front teeth in children (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
0.5% bupivacaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario… Injectable local anaesthetic agents for dental anaesthesia (2018) · Cochrane | SoF: Not measured. | 0 studies | No studies |
4% articaine, 1:200,000 epinephrine vs 0.5% bupivacaine, 1:200,000 epinephrine Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario… Injectable local anaesthetic agents for dental anaesthesia (2018) · Cochrane | SoF: Not measured. | 0 studies | No studies |
GTR rm + CAF vs SCTG + CAF Aesthetic condition change related to patient's opinion · Adult patients with single (localised) recession-type defects (Miller Class I/II, at least 3 mm) · Short term (6 to 12 months) Root coverage procedures for treating localised and multiple recession‐type defects (2018) · Cochrane | Aesthetic condition change related to patient's opinion: Not reported (SoF 5) | 0 studies | No studies |
Prenatal passive tobacco exposure (maternal smoking during pregnancy / in the womb) vs No passive tobacco exposure (non-exposed children) Dental caries in permanent dentition (presence) · Children and adolescents (permanent dentition) · Prenatal exposure; permanent dentition Association between passive tobacco exposure and caries in children and adolescents. A systematic review and… (2018) | no estimate extracted | 0 studies | No studies |
Slow-release fluoride device (fluoride glass beads) vs Placebo or usual care (control) Dental pain due to decay · Children with high risk of dental decay Slow‐release fluoride devices for the control of dental decay (2018) · Cochrane | No evidence found | 0 studies | No studies |
4% articaine, 1:200,000 epinephrine vs 4% articaine, 1:100,000 epinephrine Adverse effects: paraesthesia following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario… Injectable local anaesthetic agents for dental anaesthesia (2018) · Cochrane | SoF: Not measured. | 0 studies | No studies |
PRF + CAF vs SCTG + CAF Aesthetic condition change related to patient's opinion · Adult patients with multiple recession-type defects (Miller Class I/II, at least 3 mm) · Short term (6 to 12 months) Root coverage procedures for treating localised and multiple recession‐type defects (2018) · Cochrane | Aesthetic condition change was not reported for this comparison | 0 studies | No studies |
Ball (stud) attachment system vs Telescopic attachment system Cost (treatment time and/or material costs) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures) Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane | no estimate extracted | NR | No studies |
Non-surgical technique vs No treatment Outcome NR · People of any age with oro-antral communications, fistulae, or both caused by dental procedures Interventions for treating oro‐antral communications and fistulae due to dental procedures (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
Planned, regular routine scale and polish (6-monthly; 12-monthly parallel) vs No scheduled scale and polish treatment Adverse events · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental… Routine scale and polish for periodontal health in adults (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine Adverse effects: pain on injection (solution deposition) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario… Injectable local anaesthetic agents for dental anaesthesia (2018) · Cochrane | SoF: Not measured. | 0 studies | No studies |
ADMG + CAF vs SCTG + CAF Aesthetic condition change related to patient's opinion · Adult patients with single (localised) recession-type defects (Miller Class I/II, at least 3 mm) · Short term (6 to 12 months) Root coverage procedures for treating localised and multiple recession‐type defects (2018) · Cochrane | Aesthetic condition change related to patient's opinion: Not reported (SoF main comparison) | 0 studies | No studies |
Composite (chemical or light cured) vs Resin-modified glass ionomer cement Outcome NR · Patients with fixed orthodontic appliances attached to their teeth · To end of appliance treatment Adhesives for fixed orthodontic brackets (2018) · Cochrane | No included studies involved a comparison with resin-modified glass ionomer cement (a planned adhesive group). The authors recommended future randomised controlled trials involving resin-modified light cured glass… | 0 studies | No studies |
SPT performed by non-specialist clinicians (general dental practitioners under specialist prescription) vs SPT performed by specialists (specialist practice) Tooth loss · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT) Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis (2018) · Cochrane | Not measured | 0 studies | No studies |
Orthodontic treatment without extraction of permanent teeth (removable, fixed, or functional braces, or headgear) vs No treatment (or delayed treatment) Gingival and TMJ symptoms · Children (80% aged <= 16 years) with a Class II division 2 malocclusion (deep bite and retroclined upper front teeth) Orthodontic treatment for deep bite and retroclined upper front teeth in children (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo (placebo solution/mouthwash) Change in haemoglobin level from baseline · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and… Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral… (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
Altered-cast impression technique (ACIP), polyether vs One-piece cast technique (OPC), polyether Participant-reported oral health-related quality of life · Partially edentulous people requiring a tooth- and tissue-supported (distal-extension) removable partial denture Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | Not measured | 0 studies | No studies |
Autologous platelet concentrates (APC) + enamel matrix derivative (EMD) vs EMD (enamel matrix derivative) alone Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane | No quantitative analysis regarding patients' quality of life was possible (no data). | 0 studies | No studies |
3% prilocaine, 0.03 IU felypressin vs 2% lidocaine, 1:100,000 epinephrine Duration of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario… Injectable local anaesthetic agents for dental anaesthesia (2018) · Cochrane | SoF: Not measured. | 0 studies | No studies |
SHMP chewing gum vs Placebo Adverse effects · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline… Home‐based chemically‐induced whitening (bleaching) of teeth in adults (2018) · Cochrane | Not reported | NR | No studies |
Orthodontic treatment without extraction of permanent teeth (removable, fixed, or functional braces, or headgear) vs No treatment (or delayed treatment) Participant discomfort · Children (80% aged <= 16 years) with a Class II division 2 malocclusion (deep bite and retroclined upper front teeth) Orthodontic treatment for deep bite and retroclined upper front teeth in children (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
Antifibrinolytic agents (tranexamic acid (TXA) or epsilon aminocaproic acid (EACA)) vs Placebo, no intervention, or usual care Outcome NR · People on continuous direct oral anticoagulant (DOAC) treatment undergoing oral or dental procedures Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral… (2018) · Cochrane | no estimate extracted | 0 studies | No studies |
Late treatment (one-phase) with removable functional appliance vs No treatment Incidence of incisal trauma · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II… · End of orthodontic treatment Orthodontic treatment for prominent upper front teeth (Class II malocclusion) in children and adolescents (2018) · Cochrane | Incidence of incisal trauma: Not measured | NR | No studies |
CP paint-on gel vs HP paint-on gel Adverse effects · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline… Home‐based chemically‐induced whitening (bleaching) of teeth in adults (2018) · Cochrane | Not reported | NR | No studies |
Laterally positioned flap (LPF) vs Any other root coverage procedure Outcome NR · Adult patients with single (localised) recession-type defects (Miller Class I/II, at least 3 mm) Root coverage procedures for treating localised and multiple recession‐type defects (2018) · Cochrane | We did not find any RCTs evaluating laterally positioned flaps (LPF) | 0 studies | No studies |
4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine Duration of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario… Injectable local anaesthetic agents for dental anaesthesia (2018) · Cochrane | SoF: Not measured. | 0 studies | No studies |
Tooth-supported removable partial denture: same impression material, different final-impression technique vs The same material with an alternative final-impression technique Outcome NR · Partially edentulous people requiring a removable partial denture Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane | We did not find any trials for this comparison. | 0 studies | No studies |
Any surgical or non-surgical technique or material used for the treatment of post-extraction bleeding vs Another active intervention, placebo, or no treatment Patient-reported outcomes related to pain or discomfort during the procedure · People of any age and either gender with post-extraction bleeding, regardless of type of teeth (anterior or posterior,… Interventions for treating post‐extraction bleeding (2018) · Cochrane | No data are available as no RCTs have been conducted on interventions to treat post-extraction bleeding | 0 studies | No studies |
GTR rm + CAF vs GTR nrm + CAF Aesthetic condition change related to patient's opinion · Adult patients with single (localised) recession-type defects (Miller Class I/II, at least 3 mm) · Short term (6 to 12 months) Root coverage procedures for treating localised and multiple recession‐type defects (2018) · Cochrane | Aesthetic condition change was not reported for this comparison | 0 studies | No studies |
Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft) Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane | No quantitative analysis regarding patients' quality of life was possible (no data). | 0 studies | No studies |
Pedicled buccal fat pad flap (PBFPF) vs Buccal flap (BF) Time required for healing · People of any age with oro-antral communications, fistulae, or both caused by dental procedures Interventions for treating oro‐antral communications and fistulae due to dental procedures (2018) · Cochrane | no estimate extracted | 0 studies | No studies |