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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
856 questions in 87 reviews · Cystic Fibrosis and Genetic Disorders
current versionsNo studies 856 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Long‐term red cell transfusion vs no transfusion Measures of neurological impairment ‐ not reported · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions… Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Long‐term red cell transfusion vs no transfusion Quality of life ‐ not reported · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions… Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Long‐term red cell transfusion vs hydroxyurea and phlebotomy Measures of neurological impairment ‐ not reported · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions… Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Long‐term red cell transfusion vs hydroxyurea and phlebotomy Quality of life ‐ not reported · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions… Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Long‐term red cell transfusion vs hydroxyurea and phlebotomy Measures of neurological impairment ‐ not reported · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent… Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Long‐term red cell transfusion vs hydroxyurea and phlebotomy Quality of life ‐ not reported · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent… Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Aggressive vs conservative blood transfusion Quality of life · people with SCD Preoperative blood transfusions for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Silboesterol vs placebo Detumescence · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Sildenafil vs placebo Effect on later sexual function · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Sildenafil vs placebo Other untoward side effects of treatment · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Sildenafil vs placebo Efficacy of a prevention strategy · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Etilefrine vs placebo Detumescence · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Etilefrine vs placebo Effect on later sexual function · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Etilefrine vs placebo Other untoward side effects of treatment · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Etilefrine vs placebo Efficacy of a prevention strategy · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Ephedrine vs placebo Detumescence · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Ephedrine vs placebo Effect on later sexual function · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Ephedrine vs placebo Other untoward side effects of treatment · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Ephedrine vs placebo Efficacy of a prevention strategy · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Silboesterol vs placebo Immediate side effects of treatment · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Silboesterol vs placebo Effect on later sexual function · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Silboesterol vs placebo Other untoward side effects of treatment · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Silboesterol vs placebo Efficacy of a prevention strategy · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Sildenafil vs placebo Detumescence · men and boys with SCD and stuttering priapism Treatments for priapism in boys and men with sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Ciklavit® vs placebo Frequency of hospital admissions from severe complications of SCD · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Ciklavit® vs placebo Frequency of blood transfusion · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Ciklavit® vs placebo Quality of life measures · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Pfaffia paniculata vs placebo Frequency of hospital admissions from severe complications of SCD · children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Niprisan® vs placebo Frequency of blood transfusion · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Ciklavit® vs placebo Frequency of severe complications of SCD · adults and children with SCD Phytomedicines (medicines derived from plants) for sickle cell disease (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: NPH insulin vs glargine HbA1c · adults with CFRD and fasting hyperglycemia Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: NPH insulin vs glargine FEV1 % predicted · adults with CFRD and fasting hyperglycemia Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: NPH insulin vs glargine FVC % predicted · adults with CFRD and fasting hyperglycemia Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: NPH insulin vs glargine BMI kg/m² · adults with CFRD and fasting hyperglycemia Drug treatments for managing cystic fibrosis‐related diabetes (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: respiratory muscle training vs control Respiratory muscle function: inspiratory capacity · adults and children with cystic fibrosis Respiratory muscle training for cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Oscillating devices vs breathing techniques Frequency of exacerbationsb · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Oscillating devices vs different oscillating devices Sputum: volume · adults and children with cystic fibrosis Oscillating devices for airway clearance in people with cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings for combination antimicrobial susceptibility testing vs conventional treatment (separate testing) Lung function(FEV1 or FVC L/min or % predicted) · adults and children with pulmonary exacerbation due to Pseudomonas aeruginosa Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas… (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings for combination antimicrobial susceptibility testing vs conventional treatment (separate testing) Quality of life · adults and children with pulmonary exacerbation due to Pseudomonas aeruginosa Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas… (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings for combination antimicrobial susceptibility testing vs conventional treatment (separate testing) Length of hospital stay · adults and children with pulmonary exacerbation due to Pseudomonas aeruginosa Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas… (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings for combination antimicrobial susceptibility testing vs conventional treatment (separate testing) Sputum bacterial density (CFU/mL) · adults and children with pulmonary exacerbation due to Pseudomonas aeruginosa Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas… (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings for combination antimicrobial susceptibility testing vs conventional treatment (separate testing) Adverse events · adults and children with pulmonary exacerbation due to Pseudomonas aeruginosa Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas… (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings for combination antimicrobial susceptibility testing vs conventional treatment (separate testing) Mortality · adults and children with pulmonary exacerbation due to Pseudomonas aeruginosa Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas… (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: garlic supplementation vs placebo Need for antibiotics days of antibiotic use · children aged over eight and adults with cystic fibrosis and chronic pulmonary infection with P aeruginosa Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: garlic supplementation vs placebo QoL · children aged over eight and adults with cystic fibrosis and chronic pulmonary infection with P aeruginosa Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: garlic supplementation vs placebo Sputum microbiology · children aged over eight and adults with cystic fibrosis and chronic pulmonary infection with P aeruginosa Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: garlic supplementation vs placebo Inflammatory markers · children aged over eight and adults with cystic fibrosis and chronic pulmonary infection with P aeruginosa Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: nitric oxide vs placebo Pulmonary exacerbations · children (12 or over) and young adults with cystic fibrosis Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: nitric oxide vs placebo Need for antibiotics · children (12 or over) and young adults with cystic fibrosis Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: nitric oxide vs placebo QoL · children (12 or over) and young adults with cystic fibrosis Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |