Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,916 questions · 3,207 findings · 167 reviews · related questions CL0289

No studies found 596 · 18.6%GRADE not reported 1,666 · 51.9%Very low 603 · 18.8%Low 252 · 7.9%Moderate 78 · 2.4%High 12 · 0.4%

Osteotomes with mallet (Summers' technique) vs Rotary instruments (Cosci technique)

Complications · Patients undergoing crestal maxillary sinus lift

Osteotomes with mallet (Summers' technique) showed no clear difference in complications compared with rotary instruments (Cosci technique); GRADE not reported.

1 finding from 1 review

Systemic interventions (aciclovir, thalidomide, corticosteroids, rebamipide, etanercept, colchicine, interferon-alpha) vs placebo

Episode frequency associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • SoF 2 (systemic interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim; the review's wording "topical" is a typo for systemic): "8 placebo-controlled trials evaluated topical…
    Studies not reported
    GRADE not reported

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Alteration of hyperdivergent growth pattern · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    End of treatment (about 2 years)
    Multiple cephalometric measures reported (Erbay 1995). Treated group: total anterior facial height (N-Me) +3.9 (SD 1.8) mm, upper anterior facial height (N-ANS) +3.3 (SD 1.2) mm; controls showed significantly greater…
    1 study
    GRADE not reported

Intraligamental injection local anaesthetic vs no treatment

Postoperative pain · Children and young people aged 17 years or younger having dental treatment (including extractions) under general anaesthesia (secondary…
1 finding from 1 review

Surgical anchorage (mini-screw or mid-palatal implant) vs Conventional anchorage (headgear, transpalatal/palatal arch, etc.)

Duration of overall treatment · Patients of any age undergoing orthodontic treatment with fixed appliances and requiring anchorage (adolescents to adults up to 48-54 years)

Surgical anchorage (mini-screw or mid-palatal implant) showed no clear difference in duration of overall treatment compared with conventional anchorage (headgear, transpalatal/palatal arch, etc.) (low certainty).

1 finding from 1 review

Sucralfate suspension (topical) vs Placebo suspension

Number of painful days · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Sucralfate suspension (topical) showed no clear difference in number of painful days compared with placebo suspension; GRADE not reported.

1 finding from 1 review

Infiltration injection local anaesthetic vs no treatment or placebo

Postoperative pain or distress · Children and young people aged 17 years or younger having dental treatment (including extractions) under general anaesthesia (secondary…
1 finding from 1 review

Pre-drilling mini-screw implant vs Self-drilling mini-screw implant

Success of the anchorage device · Patients undergoing orthodontic treatment requiring surgical (mini-screw implant) anchorage

Pre-drilling mini-screw implant showed no clear difference in success of the anchorage device compared with self-drilling mini-screw implant; GRADE not reported.

1 finding from 1 review

Dual mini-screw implant vs Single mini-screw implant

Mesiodistal movement of the upper first permanent molar · Patients undergoing orthodontic treatment requiring surgical (mini-screw implant) anchorage

Dual mini-screw implant led to higher mesiodistal movement of the upper first permanent molar compared with single mini-screw implant; GRADE not reported.

1 finding from 1 review

Steri-Oss acid-etched titanium screws vs Southern blasted/etched titanium screws

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

Steri-Oss acid-etched titanium screws showed no clear difference in implant failure compared with southern blasted/etched titanium screws; GRADE not reported.

1 finding from 1 review

Southern regular implants vs Neoss turned implants

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

Southern regular implants showed no clear difference in implant failure compared with neoss turned implants; GRADE not reported.

1 finding from 1 review

Colchicine (0.5 mg three times per day) vs placebo

Improvement in oral ulcer score · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Colchicine (systemic; 0.5 mg three times daily for 6 months) showed no clear difference in improvement in oral ulcer score compared with placebo; GRADE not reported.

1 finding from 1 review

Powered toothbrush, unknown/other action vs Manual toothbrush

Plaque · Individuals of any age with no reported disability that might affect toothbrushing (including people wearing orthodontic appliances)
1 finding from 1 review
  • Powered versus manual toothbrushing for oral health 2014 · Cochrane All outcomes
    Short term (1 to 3 months)
    Unknown/other action vs manual, plaque at 1 to 3 months: 2 trials; totals not selected (data presented in forest plots but not pooled owing to lack of clarity about the toothbrushes).
    2 studies
    GRADE not reported

Topical interventions (sucralfate, interferon-alpha, cyclosporin A) vs placebo

Pain associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • SoF (topical interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim): "5 placebo-controlled trials evaluated topical interventions (sucralfate suspension (2 trials), interferon-alpha (2…
    Studies not reported
    GRADE not reported

One-stage lateral sinus lift with monocortical autogenous bone blocks (iliac crest) vs Two-stage lateral sinus lift with autogenous particulate bone (iliac crest)

Prosthesis failure · Patients with 2 to 7 mm of residual alveolar bone height in the edentulous maxillary sinus floor

One-stage lateral sinus lift with monocortical autogenous bone… showed no clear difference in prosthesis failure compared with two-stage lateral sinus lift with autogenous particulate bone (iliac…; GRADE not reported.

1 finding from 1 review

Sinus lift with bone graft (granular Bio-Oss) vs Sinus lift without bone graft (Inion resorbable rigid barrier maintaining space / no bone)

Complications · Patients with an atrophic maxillary sinus requiring augmentation (1 to 5 mm residual bone height)

Sinus lift with bone graft (granular Bio-Oss) showed no clear difference in complications compared with sinus lift without bone graft (Inion resorbable rigid barrier…; GRADE not reported.

1 finding from 1 review

Surgical anchorage (mini-screw or mid-palatal implant) vs Conventional anchorage (headgear, transpalatal/palatal arch, etc.)

Duration of space closure · Patients of any age undergoing orthodontic treatment with fixed appliances and requiring anchorage (adolescents to adults up to 48-54 years)

Surgical anchorage (mini-screw or mid-palatal implant) showed no clear difference in duration of space closure compared with conventional anchorage (headgear, transpalatal/palatal arch, etc.); GRADE not reported.

1 finding from 1 review