Behaviour · Children and adolescents (0 to 16 years) needing dental treatment
It is very uncertain whether oral diazepam changes behaviour (Houpt/behavioural score) compared with placebo (including no intervention) (very low certainty).
1 finding from 1 review
Duration of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
The review found no eligible studies for this question.
1 finding from 1 review
SoF: Not measured.
0 studies
No studies found
Success of local anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
0.5% bupivacaine, 1:200,000 epinephrine showed no clear difference in success of local anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).
1 finding from 1 review
Speed of onset of anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
It is very uncertain whether 4% articaine, 1:100,000 epinephrine changes speed of onset of anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).
1 finding from 1 review
Success of local anaesthesia (soft tissue, self-reported; 100% success in all studies) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
'Other comparisons with 100% success': IANB - Sampaio 2012 35/35 vs 35/35; Fernandez 2005 39/39 vs 39/39. Both formulations 100% successful; no meta-analysis (no difference).
2 studies · 74 participants
GRADE not reported
Behaviour · Children and adolescents (0 to 16 years) needing dental treatment
It is very uncertain whether intravenous midazolam changes behaviour (Houpt/behavioural score) compared with placebo (including no intervention) (very low certainty).
1 finding from 1 review
Speed of onset of anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
It is very uncertain whether 4% articaine plain changes speed of onset of anaesthesia (pulpal, electric pulp tester; healthy… compared with 4% articaine, 1:200,000 epinephrine (very low certainty).
1 finding from 1 review
Speed of onset of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
The review found no eligible studies for this question.
1 finding from 1 review
SoF: Not measured.
0 studies
No studies found
Success of local anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
4% prilocaine, 1:200,000 epinephrine showed no clear difference in success of local anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).
1 finding from 1 review
Success of local anaesthesia, absence of pain (clinical testing of healthy pulps, hard and soft tissues) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
3% prilocaine, 0.03 IU felypressin probably leads to lower success of local anaesthesia, absence of pain (clinical testing of… compared with 2% lidocaine, 1:100,000 epinephrine (moderate certainty).
1 finding from 1 review
Success of local anaesthesia, absence of pain (clinical testing of healthy pulps, hard and soft tissues) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
It is very uncertain whether 4% articaine, 1:200,000 epinephrine changes success of local anaesthesia, absence of pain (clinical testing of… compared with 4% articaine, 1:100,000 epinephrine (very low certainty).
1 finding from 1 review
Success of local anaesthesia (clinical; orphan data) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
No data available for meta-analysis; orphan clinical success data summarized in Table 6 (e.g. clinical anaesthesia success 2% lidocaine 1:100,000 64/110 vs 2% mepivacaine 1:20,000 levonordefrin 99/113). Not…
Studies not reported
GRADE not reported
Duration of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
4% articaine, 1:100,000 epinephrine may leads to higher duration of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).
1 finding from 1 review
Duration of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
It is very uncertain whether 4% articaine, 1:200,000 epinephrine changes duration of anaesthesia (soft tissue, simulated) compared with 0.5% bupivacaine, 1:200,000 epinephrine (very low certainty).
1 finding from 1 review
Speed of onset of anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
It is very uncertain whether 4% articaine, 1:200,000 epinephrine changes speed of onset of anaesthesia (pulpal, electric pulp tester; healthy… compared with 4% articaine, 1:100,000 epinephrine (very low certainty).
1 finding from 1 review
Success of local anaesthesia (clinical/EPT; orphan data) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
Behaviour · Children and adolescents (0 to 16 years) needing dental treatment
Oral midazolam probably leads to higher behaviour (Houpt/behavioural score) compared with placebo (including no intervention) (moderate certainty).
1 finding from 1 review
Rescue analgesia · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Ibuprofen taken pre-emptively (about 1 hour before treatment) showed no clear difference in rescue analgesia compared with ibuprofen taken post-treatment; GRADE not reported.
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) probably leads to lower pain intensity (VAS 0-100 mm) compared with control (placebo or no treatment) (moderate certainty).
3 findings from 1 review
MD -11.66 [-16.15, -7.17]
10 studies · 685 participants
Moderate
MD -21.19 [-28.31, -14.06]
12 studies · 1012 participants
Moderate
MD -24.27 [-31.44, -17.11]
9 studies · 535 participants
Moderate
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
It is very uncertain whether ibuprofen taken pre-emptively (about 1 hour before treatment) changes pain intensity (VAS 0-100 mm) compared with ibuprofen taken post-treatment (very low certainty).
3 findings from 1 review
MD -9.74 [-47.88, 28.40]
2 studies · 69 participants
Very low
MD -11.30 [-16.27, -6.33]
1 study · 41 participants
Very low
MD -8.43 [-30.37, 13.50]
2 studies · 69 participants
Very low