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Evidence found and GRADE certainty

3,032 questions · 3,358 findings · 190 reviews · related questions CL0289

No studies found 599 · 17.8%GRADE not reported 1,759 · 52.4%Very low 612 · 18.2%Low 269 · 8%Moderate 107 · 3.2%High 12 · 0.4%

Biodentine vs Tempophore

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Biodentine showed no clear difference in radiological failure compared with tempophore; GRADE not reported.

1 finding from 1 review

Early treatment (two-phase) with headgear vs Early treatment (two-phase) with functional appliance

Final ANB · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase) with headgear showed no clear difference in final ANB compared with early treatment (two-phase) with functional appliance; GRADE not reported.

2 findings from 1 review

SPT using one technique or appliance for mechanical root debridement vs SPT using a different technique or appliance for mechanical root debridement

Outcome not reported · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

The review found no eligible studies for this question.

1 finding from 1 review

GTR rm associated with bone substitutes + CAF vs GTR rm + CAF

Keratinized tissue width change · Adult patients with single (localised) recession-type defects (Miller Class I/II, at least 3 mm)

GTR rm associated with bone substitutes + CAF showed no clear difference in keratinized tissue width change compared with GTR rm + CAF; GRADE not reported.

1 finding from 1 review

Fixed functional appliance (FORSUS FRD) vs Fixed functional appliance with mini-implants (FMI)

Final ANB · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

Fixed functional appliance (FORSUS FRD) showed no clear difference in final ANB compared with fixed functional appliance with mini-implants (FMI); GRADE not reported.

1 finding from 1 review

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

Long-term skeletal relapse/stability (horizontal movement of A-point) · Adolescents or adults (15 years or older) with an established diagnosis of complete cleft lip and alveolar process, or complete unilateral…

It is very uncertain whether maxillary distraction osteogenesis changes long-term skeletal relapse/stability (horizontal movement of A-point) compared with orthognathic surgery (conventional Le Fort I osteotomy) (very low certainty).

1 finding from 1 review

Zinc oxide and eugenol (ZOE) vs Zinc oxide and propolis (ZOP)

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth

The review found no eligible studies for this question.

1 finding from 1 review

18% CP paint-on gel vs placebo

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 18% CP paint-on gel changes tooth whitening - assessed by the dentist compared with placebo (very low certainty).

1 finding from 1 review

Self-etch adhesive + acetone-based total-etch adhesive vs Acetone-based total-etch adhesive

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes clinical failure compared with acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Chemical cured composite vs Glass ionomer cement (GIC)

Decalcification · Patients with fixed orthodontic appliances attached to their teeth

The review found no eligible studies for this question.

1 finding from 1 review
  • Adhesives for fixed orthodontic brackets 2018 · Cochrane All outcomes
    To end of appliance treatment
    It was surprising that decalcification rates were not reported as a secondary outcome, as clinically it is suggested that GIC is protective against decalcification; the…
    0 studies
    No studies found

SPT performed by non-specialist clinicians (general dental practitioners under specialist prescription) vs SPT performed by specialists (specialist practice)

Probing pocket depth · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

It is very uncertain whether SPT performed by non-specialist clinicians (general dental… changes probing pocket depth (mm) compared with SPT performed by specialists (specialist practice) (very low certainty).

1 finding from 1 review

Autologous platelet concentrates (APC) + enamel matrix derivative (EMD) vs EMD (enamel matrix derivative) alone

Attachment change · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + enamel matrix derivative… changes change in clinical attachment level (CAL) (mm) compared with EMD (enamel matrix derivative) alone (very low certainty).

1 finding from 1 review