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Evidence found and GRADE certainty

3,032 questions · 3,358 findings · 190 reviews · related questions CL0289

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No studies found 599 · 17.8%GRADE not reported 1,759 · 52.4%Very low 612 · 18.2%Low 269 · 8%Moderate 107 · 3.2%High 12 · 0.4%

Glutaraldehyde + zinc oxide and eugenol (ZOE) vs Full strength formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Glutaraldehyde + zinc oxide and eugenol (ZOE) showed no clear difference in clinical failure compared with full strength formocresol (FC); GRADE not reported.

1 finding from 1 review

Autologous platelet concentrates (APC) + open flap debridement (OFD) vs Open flap debridement (access flap surgery)

Change in probing pocket depth (PPD) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD) changes change in probing depth (PD) (mm) compared with OFD (open flap debridement) alone (very low certainty).

1 finding from 1 review

Bilateral extraction of compromised mandibular first permanent molars vs Age- and gender-matched non-extraction controls

Lower incisor inclination (lingual tipping and retrusion) · Children (approximately 11 years or older) with compromised mandibular first permanent molars

Bilateral lower first permanent molar extraction was associated with lingual tipping and retrusion of the lower incisors in one case-control study; ungraded.

1 finding from 1 review

6% HP strip vs 10% CP gel in tray

Tooth whitening - assessed by the dentist · Adults (>=18 years) undergoing home-based bleaching (including tetracycline- and smoking-stained teeth, any baseline shade)

It is very uncertain whether 6% HP strip changes tooth whitening - assessed by the dentist compared with 10% CP gel in tray (very low certainty).

2 findings from 1 review

Autologous platelet concentrates (APC) + open flap debridement (OFD) vs Open flap debridement (access flap surgery)

Tooth survival · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
1 finding from 1 review

Fixed functional appliance (FORSUS FRD) vs Fixed functional appliance with mini-implants (FMI)

Final overjet · Adolescents (age 12 to 16 years) receiving orthodontic treatment to correct prominent upper front teeth (Class II malocclusion)

Fixed functional appliance (FORSUS FRD) showed no clear difference in final overjet compared with fixed functional appliance with mini-implants (FMI); GRADE not reported.

1 finding from 1 review

3% mepivacaine plain vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (soft tissue, self-reported; 100% success in all studies) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
  • Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
    '100% success' (lidocaine 1:100,000 vs 3% mepivacaine plain): infraorbital block - Berberich 2009 40/40 vs 40/40; IANB - Cohen 1993 27/27 vs 34/34, McLean 1993 30/30 vs 30/30. Both 100% successful.
    3 studies · 121 participants
    GRADE not reported

Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft)

Change in radiographic bone defect filling (RBF) (%) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

Autologous platelet concentrates (APC) + open flap debridement (OFD)… led to higher change in radiographic bone defect filling (RBF) (%) compared with OFD + BG (open flap debridement + bone graft); GRADE not reported.

3 findings from 1 review

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) may leads to lower radiological failure compared with calcium hydroxide (CH) (low certainty).

2 findings from 1 review

4% articaine, 1:200,000 epinephrine vs 4% articaine, 1:100,000 epinephrine

Duration of anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% articaine, 1:200,000 epinephrine changes duration of anaesthesia (pulpal, electric pulp tester; healthy pulps) compared with 4% articaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

Ferric sulphate (FS) + mineral trioxide aggregate (MTA) vs Mineral trioxide aggregate (MTA)

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
  • Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
    mean 22 months
    Assessed pain, soft tissue pathology, mobility, radiolucency, root resorption, pulp canal obliteration (Doyle 2010); no clinical/radiological failure outcome; no significant differences
    1 study · 130 participants
    GRADE not reported

Single-stage alginate impression (simplified method) vs Two stage-two step zinc-oxide eugenol (ZoE) traditional method

Participant-reported quality of the denture (general satisfaction) · Completely edentulous people

It is very uncertain whether single-stage alginate impression (simplified method) changes participant-reported quality of the denture (general satisfaction) compared with two stage-two step zinc-oxide eugenol (ZoE) traditional method (very low certainty).

1 finding from 1 review

4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% prilocaine plain showed no clear difference in success of local anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).

1 finding from 1 review

Ball (stud) attachment system vs Bar attachment system

Re-treatment: replacement of attachment system (short term) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures)

It is very uncertain whether ball (stud) attachment system changes re-treatment: replacement of attachment system (short term) compared with bar attachment system (very low certainty).

1 finding from 1 review