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Evidence found and GRADE certainty

119 questions · 137 findings · 9 reviews · Other oral health · related questions CL0289

No studies found 29 · 21.2%GRADE not reported 57 · 41.6%Very low 16 · 11.7%Low 34 · 24.8%Moderate 1 · 0.7%High 0 · 0%

Interferon-alpha 1000 IU lozenges (topical) vs Interferon-alpha 2000 IU lozenges (topical)

Total ulcer burden · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
    Interferon-alpha dose comparison
    Kilic 2009 (interferon-alpha 1000 IU vs 2000 IU lozenges, 84 patients): the data presented did not allow analysis; authors reported no statistically significant difference in total ulcer burden between the two doses.
    1 study · 84 participants
    GRADE not reported

Systemic interventions (aciclovir, thalidomide, corticosteroids, rebamipide, etanercept, colchicine, interferon-alpha) vs placebo

Episode frequency associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • SoF 2 (systemic interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim; the review's wording "topical" is a typo for systemic): "8 placebo-controlled trials evaluated topical…
    Studies not reported
    GRADE not reported

Sucralfate suspension (topical) vs Placebo suspension

Number of painful days · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Sucralfate suspension (topical) showed no clear difference in number of painful days compared with placebo suspension; GRADE not reported.

1 finding from 1 review

Colchicine (0.5 mg three times per day) vs placebo

Improvement in oral ulcer score · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Colchicine (systemic; 0.5 mg three times daily for 6 months) showed no clear difference in improvement in oral ulcer score compared with placebo; GRADE not reported.

1 finding from 1 review

Topical interventions (sucralfate, interferon-alpha, cyclosporin A) vs placebo

Pain associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • SoF (topical interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim): "5 placebo-controlled trials evaluated topical interventions (sucralfate suspension (2 trials), interferon-alpha (2…
    Studies not reported
    GRADE not reported

Thalidomide (systemic; 100 mg or 300 mg daily) vs placebo

Number of (minor aphthous) oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
    Males only
    Hamuryudan 1998 (thalidomide 100 mg or 300 mg daily vs placebo, 101 male patients; high risk of reporting bias): a significant effect on mean numbers of minor oral ulcers was reported from week 4 in both thalidomide…
    1 study · 101 participants
    GRADE not reported

Cyclosporin A in orabase (topical) vs Placebo (orabase)

Oral ulcers (number, size, healing time) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Ergun 1997 (cyclosporin A in orabase vs placebo orabase, 24 patients; high risk of reporting bias): no data were presented; authors reported no clinical improvement in the number, size, and healing time of ulcers for…
    1 study · 24 participants
    GRADE not reported

Depot corticosteroids (systemic; 40 mg methylprednisolone IM every 3 weeks for 27 weeks) vs placebo injection

Mean number of oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Depot corticosteroids (systemic; 40 mg methylprednisolone IM every 3… showed no clear difference in mean number of oral ulcers compared with placebo (saline IM injection); GRADE not reported.

1 finding from 1 review

Cyclosporin (systemic; 10 mg/kg/day for 16 weeks) vs Colchicine (systemic; 1 mg daily)

Alleviation of oral aphthous ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Cyclosporin (systemic; 10 mg/kg/day for 16 weeks) led to higher alleviation of oral aphthous ulcers compared with colchicine (systemic; 1 mg daily); GRADE not reported.

1 finding from 1 review

Sucralfate suspension (topical) vs Placebo suspension

Episode frequency associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Sucralfate suspension (topical) showed no clear difference in frequency of oral ulcers compared with placebo suspension; GRADE not reported.

1 finding from 1 review

Topical interventions (sucralfate, interferon-alpha, cyclosporin A) vs placebo

Episode duration associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • SoF (topical interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim): "5 placebo-controlled trials evaluated topical interventions (sucralfate suspension (2 trials), interferon-alpha (2…
    Studies not reported
    GRADE not reported

Capitation remuneration vs Fee-for-service remuneration

Measures of non-clinical behaviour: proportion of dentists introducing innovations into their dental practices · Children (0- to 15-year-olds) undergoing routine continuing dental care at 354 dental practices, in matched pairs of Health Service…

Capitation remuneration led to lower measures of non-clinical behaviour: proportion of dentists… compared with fee-for-service remuneration; GRADE not reported.

1 finding from 1 review

Capitation remuneration vs Fee-for-service remuneration

Patient outcomes: mean percentage of 0- to 15-year-olds having one or more teeth extracted · Children (0- to 15-year-olds) undergoing routine continuing dental care at 354 dental practices, in matched pairs of Health Service…

Capitation remuneration may leads to lower patient outcomes: mean percentage of 0- to 15-year-olds having one… compared with fee-for-service remuneration (low certainty).

4 findings from 1 review
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Capitation remuneration vs Fee-for-service remuneration

Measures of health service utilisation: mean number of visits per 0- to 15-year-old · Children (0- to 15-year-olds) undergoing routine continuing dental care at 354 dental practices, in matched pairs of Health Service…

Capitation remuneration showed no clear difference in measures of health service utilisation: mean number of visits per 0-… compared with fee-for-service remuneration (low certainty).

4 findings from 1 review
Show 1 more finding

Capitation remuneration vs Fee-for-service remuneration

Mean number of decayed teeth (mean DT) · Children (0- to 15-year-olds) undergoing routine continuing dental care at 354 dental practices, in matched pairs of Health Service…

Capitation remuneration showed no clear difference in patient outcomes: mean number of decayed teeth per 14- to… compared with fee-for-service remuneration (low certainty).

4 findings from 1 review
Show 1 more finding

Capitation remuneration vs Fee-for-service remuneration

Unintended effects: self-reported temptation to under-prescribe (0- to 100-point visual analogue scale) · Children (0- to 15-year-olds) undergoing routine continuing dental care at 354 dental practices, in matched pairs of Health Service…

Capitation remuneration showed no clear difference in unintended effects: self-reported temptation to under-prescribe (0-… compared with fee-for-service remuneration; GRADE not reported.

1 finding from 1 review

Capitation remuneration vs Fee-for-service remuneration

Measures of clinical activity: mean percentage of 0- to 15-year-olds receiving active preventive advice · Children (0- to 15-year-olds) undergoing routine continuing dental care at 354 dental practices, in matched pairs of Health Service…

Capitation remuneration may leads to higher measures of clinical activity: mean percentage of 0- to 15-year-olds… compared with fee-for-service remuneration (low certainty).

4 findings from 1 review
Show 1 more finding

Fee‐for‐service (FFS) vs no intervention or control intervention (control)

Measures of clinical activity: mean percentage of 12- to 14-year-olds receiving fissure sealants for second permanent molars per dentist (weighted by number of children seen) - unadjusted · Dentists seeing children with erupted second permanent molars (Scotland, in areas representing the four most deprived categories out of…

It is very uncertain whether fee-for-service remuneration changes measures of clinical activity: mean percentage of 12- to… compared with no specific intervention (control) (very low certainty).

1 finding from 1 review

Capitation remuneration vs Fee-for-service remuneration

Unintended effects: self-reported temptation to over-prescribe (0- to 100-point visual analogue scale) · Children (0- to 15-year-olds) undergoing routine continuing dental care at 354 dental practices, in matched pairs of Health Service…

Capitation remuneration showed no clear difference in unintended effects: self-reported temptation to over-prescribe (0-… compared with fee-for-service remuneration; GRADE not reported.

1 finding from 1 review

Capitation remuneration vs Fee-for-service remuneration

Patient outcomes: mean number of filled teeth per 0- to 15-year-old · Children (0- to 15-year-olds) undergoing routine continuing dental care at 354 dental practices, in matched pairs of Health Service…

Capitation remuneration showed no clear difference in patient outcomes: mean number of filled teeth per 0- to 15-year-old compared with fee-for-service remuneration (low certainty).

4 findings from 1 review
Show 1 more finding