Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

2,916 questions · 3,207 findings · 167 reviews · related questions CL0289

No studies found 596 · 18.6%GRADE not reported 1,666 · 51.9%Very low 603 · 18.8%Low 252 · 7.9%Moderate 78 · 2.4%High 12 · 0.4%

Acupuncture at P6 point vs sham

Reduction in gagging (assessor-reported – treatment effectiveness) · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

Acupuncture at P6 point showed no clear difference in reduction in gagging (assessor-reported – treatment effectiveness) compared with sham acupuncture; GRADE not reported.

1 finding from 1 review

0.6% eucalyptus chewing gum vs Placebo chewing gum

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

0.6% eucalyptus chewing gum showed no clear difference in volatile sulphur compounds (VSC) compared with placebo chewing gum; GRADE not reported.

1 finding from 1 review

Miswak (Salvadora persica) stick vs Chlorhexidine mouthwash

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Miswak (Salvadora persica) stick led to lower volatile sulphur compounds (VSC) compared with chlorhexidine mouthwash; GRADE not reported.

1 finding from 1 review

Hinokitiol gel vs Placebo gel

VSC: methyl mercaptan · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Hinokitiol gel showed no clear difference in VSC: methyl mercaptan compared with placebo gel; GRADE not reported.

1 finding from 1 review

Topical G32 (ayurvedic preparation) vs Chlorhexidine, 0.2% to 2% (solution or gel)

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Topical G32 (ayurvedic preparation) showed no clear difference in volatile sulphur compounds (VSC) compared with chlorhexidine digluconate 1% gel; GRADE not reported.

1 finding from 1 review

1000 mg champignon extract vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether 1000 mg champignon extract changes patient-reported visual analogue scale (VAS) score (scale 0 to 100) compared with placebo (very low certainty).

1 finding from 1 review

Sesame oil vs Chlorhexidine mouthwash

OLT score and patient self-assessment (BANA test) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…
1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    Asokan 2011 (2-arm trial) compared sesame oil versus chlorhexidine 0.2% mouthwash (OLT and BANA test). We could not include the results in the meta-analysis because they did not report post-intervention OLT score and P…
    1 study
    GRADE not reported

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Outcome not reported · People with Von Willebrand disease undergoing minor oral surgery or dental extractions

The review found no eligible studies for this question.

1 finding from 1 review

0.6% eucalyptus chewing gum vs Placebo chewing gum

Patient-reported OLT score · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

The review found no eligible studies for this question.

1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    mean 4 weeks
    Patient-reported OLT score: listed in the Summary of findings table but no data reported. No data were reported for patient-reported OLT score.
    0 studies
    No studies found

Scaling and root planing (SRP) plus glycine powder air polishing vs Scaling/root planing alone

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Scaling and root planing (SRP) plus glycine powder air polishing showed no clear difference in volatile sulphur compounds (VSC), halimeter compared with scaling and root planing (SRP) alone; GRADE not reported.

1 finding from 1 review

Hinokitiol gel vs Placebo gel

Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether hinokitiol gel changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with placebo gel (very low certainty).

1 finding from 1 review

1000 mg champignon extract vs placebo

Patient's family member-reported VAS score (scale 0 to 100) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

1000 mg champignon extract showed no clear difference in patient's family member-reported VAS score (scale 0 to 100) compared with placebo; GRADE not reported.

1 finding from 1 review

Hyperbaric oxygen therapy (HBO) following extractions vs penicillin G

Incidence of ORN · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)

It is very uncertain whether hyperbaric oxygen therapy (HBO) following extractions changes incidence of ORN compared with perioperative antibiotic prophylaxis (penicillin G) following… (very low certainty).

1 finding from 1 review

Thymosin alpha 1 (10-minute soak prior to replantation) vs Normal saline

Tooth survival · People with avulsed and replanted permanent (front) teeth

It is very uncertain whether thymosin alpha 1 (10-minute soak prior to replantation) changes tooth survival at 12 months compared with control (saline) (very low certainty).

2 findings from 1 review

Acupressure at P6 point with device plus sedation vs Sham (dummy) acupressure with sedation

Reduction in gagging (patient-reported) · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupressure at P6 point with device plus sedation changes reduction in gagging (patient-reported) compared with sham (dummy) acupressure with sedation (very low certainty).

1 finding from 1 review

Ledermix root canal medicament (day 0 to 10) vs Ultracal root canal medicament (day 7 to 10)

Aesthetics (discolouration) at 12 months (patient level) · People with avulsed and replanted permanent (front) teeth

It is very uncertain whether ledermix root canal medicament (day 0 to 10) changes aesthetics (discolouration) at 12 months (patient level) compared with ultracal root canal medicament (day 7 to 10) (very low certainty).

1 finding from 1 review

Acupressure at P6 point with thumb plus sedation vs Sham (dummy) acupressure with sedation

Reduction in gagging (patient-reported) · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupressure at P6 point with thumb plus sedation changes reduction in gagging (patient-reported) compared with sham (dummy) acupressure with sedation (very low certainty).

1 finding from 1 review

Systemic antibiotic (oral penicillin 500 mg) plus analgesic vs Placebo plus analgesic

Total number of ibuprofen tablets · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis

Systemic antibiotic (oral penicillin 500 mg) plus analgesic showed no clear difference in total number of ibuprofen tablets compared with placebo plus analgesic (low certainty).

1 finding from 1 review