Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
Topical triamcinolone acetonide may leads to lower pain (mean score) compared with topical curcumin (low certainty).
1 finding from 1 review
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.
3 findings from 1 review
MD -0.47 [-0.68, -0.26]
6 studies · 215 participants
GRADE not reported
MD -0.18 [-0.33, -0.04]
15 studies · 562 participants
GRADE not reported
MD -0.30 [-0.42, -0.18]
2 studies · 389 participants
Very low
Pain resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
It is very uncertain whether topical clobetasol propionate changes pain resolution compared with topical ciclosporin (very low certainty).
1 finding from 1 review
Physical/verbal resistance and self-reported pain during LA (other studies) · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
Hypnosis led to lower physical/verbal resistance and self-reported pain during LA (other… compared with conventional treatment; GRADE not reported.
1 finding from 1 review
Postoperative pain (mean) · Adults with mandibular third molars requiring removal
Triangular flap led to lower postoperative pain (mean) compared with envelope flap; GRADE not reported.
1 finding from 1 review
Reduction in contamination of aerosols on operator's face shield/mask (RCTs) · People undergoing aerosol-generating procedures (AGPs) in a dental setting
High-volume evacuation (HVE) showed no clear difference in reduction in contamination of aerosols on operator's face… compared with no HVE; GRADE not reported.
1 finding from 1 review
Probing pocket depth · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in probing pocket depth compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD 0.38 [0.00, 0.76]
3 studies · 75 participants
GRADE not reported
MD 1.00 [0.30, 1.70]
1 study · 27 participants
Very low
MD -0.16 [-0.56, 0.24]
2 studies · 49 participants
GRADE not reported
Probing pocket depth · Adults with aggressive periodontitis
Clindamycin + SRP showed no clear difference in probing pocket depth compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD -0.14 [-0.82, 0.54]
1 study · 26 participants
GRADE not reported
MD -0.10 [-0.79, 0.59]
1 study · 26 participants
GRADE not reported
MD 0.20 [-0.38, 0.78]
1 study · 26 participants
Very low
Temporary altered tongue sensation · Adults with mandibular third molars requiring removal
Lingual split with chisel showed no clear difference in temporary altered tongue sensation compared with lingual split with bur; GRADE not reported.
1 finding from 1 review
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with clarithromycin + SRP; GRADE not reported.
2 findings from 1 review
Pain (mean VAS score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
Topical clobetasol propionate showed no clear difference in pain (mean VAS score) compared with topical tacrolimus; GRADE not reported.
1 finding from 1 review
Probing pocket depth · Adults with chronic periodontitis
Amoxicillin + clavulanate + SRP showed no clear difference in probing pocket depth compared with SRP; GRADE not reported.
3 findings from 1 review
MD 0.00 [-0.19, 0.19]
1 study · 21 participants
GRADE not reported
MD 0.10 [-0.17, 0.37]
1 study · 21 participants
Very low
MD 0.20 [-0.02, 0.42]
1 study · 21 participants
GRADE not reported
Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
It is very uncertain whether topical clobetasol propionate changes clinical resolution compared with topical tacrolimus (very low certainty).
1 finding from 1 review
Reduction in pain · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review
Probing pocket depth · Adults with aggressive periodontitis
The review found no eligible studies for this question.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with aggressive periodontitis
It is very uncertain whether clindamycin + SRP changes clinical attachment level (CAL) compared with doxycycline + SRP (very low certainty).
3 findings from 1 review
MD -0.90 [-1.62, -0.18]
1 study · 23 participants
Very low
MD -0.40 [-1.15, 0.35]
1 study · 23 participants
GRADE not reported
MD 0.50 [-0.26, 1.26]
1 study · 23 participants
GRADE not reported
Self- or observational assessment of intraoperative distress/pain/acceptance of treatment during provision of LA: pain-related behaviour (any disruptive behaviour/sudden reaction/movement) · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
1 finding from 1 review
pain-related behaviour (any disruptive behaviour/sudden reaction/movement); 4 studies reported a benefit in using the wand while the remaining studies results suggested no difference between the 2 methods of delivering…
6 studies · 704 participants
Very low
Postoperative pain · Adults with mandibular third molars requiring removal
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Tetracycline + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.
3 findings from 1 review
MD -1.90 [-2.17, -1.63]
1 study · 26 participants
GRADE not reported
MD -2.30 [-2.50, -2.10]
1 study · 26 participants
Very low
MD -0.92 [-2.38, 0.54]
2 studies · 64 participants
GRADE not reported
Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
Topical triamcinolone acetonide showed no clear difference in pain (mean score) compared with intralesional BCG-polysaccharide nucleic acid (BCG-PSN); GRADE not reported.
1 finding from 1 review