Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,916 questions · 3,207 findings · 167 reviews · related questions CL0289

No studies found 596 · 18.6%GRADE not reported 1,666 · 51.9%Very low 603 · 18.8%Low 252 · 7.9%Moderate 78 · 2.4%High 12 · 0.4%

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Fever · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes fever (6th-7th day) compared with placebo (very low certainty).

1 finding from 1 review

Expansion plate with conventional expansion screw vs Expansion plate with spring-loaded expansion screw

Molar and canine expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review

ARP with allograft plus synthetic cell-binding peptide P-15 vs ARP with allograft without P-15

Aesthetic outcomes of future prosthodontic rehabilitation · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

The review found no eligible studies for this question.

1 finding from 1 review

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs Placebo

Outcome not reported · Patients undergoing tooth extraction for severe dental caries or periodontal disease in general dental practice (non-third-molar / decayed…

The review found no eligible studies for this question.

1 finding from 1 review
  • No studies in general dental practice for removal of decayed teeth. PUB3 added one routine intra-alveolar extraction trial and one complex oral surgery trial (2 of 23 non-third-molar), but the single intra-alveolar…
    0 studies
    No studies found

Azithromycin + SRP vs SRP

Probing pocket depth · Adults with periodontitis (chronic and aggressive)

Azithromycin + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.

3 findings from 1 review

Counter-stimulation and distraction (combined) vs Conventional treatment

Acceptance of LA · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Video modelling acclimatisation vs Acclimatisation in clinic (tell-show-do)

Anxiety · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

Video modelling acclimatisation showed no clear difference in pre- and post-operative anxiety measures (Venham's scale) compared with acclimatisation in clinic (tell-show-do); GRADE not reported.

1 finding from 1 review

Doxycycline + SRP vs Metronidazole + SRP

Clinical attachment level (CAL) · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with metronidazole + SRP; GRADE not reported.

3 findings from 1 review

Clinical examination with 24-month recall vs Clinical examination with 6-month recall

Patient satisfaction with actual care received (1-7 scale) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with 24-month recall showed no clear difference in patient satisfaction with actual care received (1-7 scale) compared with clinical examination with 6-month recall; GRADE not reported.

1 finding from 1 review

Metronidazole + SRP vs SRP

Probing pocket depth · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether metronidazole + SRP changes probing pocket depth compared with SRP (very low certainty).

3 findings from 1 review

Doxycycline + SRP vs SRP

Clinical attachment level (CAL) · Adults with aggressive periodontitis

It is very uncertain whether doxycycline + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).

3 findings from 1 review

Azithromycin + SRP vs SRP

Percentage of closed pockets · Adults with periodontitis (chronic and aggressive)

Azithromycin + SRP showed no clear difference in percentage of closed pockets compared with SRP; GRADE not reported.

2 findings from 1 review

Doxycycline + SRP vs SRP

Probing pocket depth · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in probing pocket depth compared with SRP; GRADE not reported.

3 findings from 1 review

General ventilation (e.g. natural ventilation, exhaust fans, opening windows) vs No general ventilation / standard operatory

Outcome not reported · Dental healthcare providers (dentist, dental surgery assistant, dental hygienist, dental technologist, dental laboratory staff, dental…

The review found no eligible studies for this question.

1 finding from 1 review