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Evidence found and GRADE certainty

741 questions · 808 findings · 27 reviews · Oral medicine and oral cancer · related questions CL0289

No studies found 95 · 11.8%GRADE not reported 498 · 61.6%Very low 134 · 16.6%Low 53 · 6.6%Moderate 27 · 3.3%High 1 · 0.1%

Carboxymethylcellulose (CMC) spray vs Salinum linseed oil spray

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
  • Andersson 1995 (crossover, n=20): more participants experienced a reduction in oral dryness with linseed (Salinum) spray than with CMC spray; crossover data not accounted for, no usable estimate.
    1 study · 20 participants
    GRADE not reported

Oxygenated glycerol triester (OGT) spray vs Saliveeze (aqueous electrolyte) spray

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…

Oxygenated glycerol triester (OGT) spray led to higher xerostomia (mouth dryness scale) compared with saliveeze (aqueous electrolyte) spray; GRADE not reported.

1 finding from 1 review

Mucin spray (Saliva Orthana) vs Placebo spray (base without mucin)

Patient satisfaction / desire to continue treatment · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…

Mucin spray (Saliva Orthana) led to lower patient satisfaction / desire to continue treatment compared with placebo spray (base without mucin); GRADE not reported.

1 finding from 1 review
  • Sweeney 1997: majority in both groups wished to continue the allocated spray, no significant difference (Analysis 1.3). Duxbury 1989: 14/30 (46.6%) and 15/30 (50%) wished to continue Saliva Orthana and the spray base…
    2 studies
    GRADE not reported

CMC spray / HCC spray / HCC gel vs Liquid margarine (and between each other)

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
  • Furumoto 1998 (crossover, n=28, medians/IQR): median day-10 oral dryness (lower = less dry): CMC spray 28.00 (3.06), HCC spray 28.75 (2.23), HCC gel 27.75 (3.62), margarine 29.25 (5.06). Only HCC gel showed a…
    1 study · 28 participants
    GRADE not reported

Cryotherapy (ice chips) 30 minutes vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Cryotherapy (ice chips) 30 minutes showed no clear difference in oral mucositis (moderate to severe) compared with cryotherapy (ice chips) 60 minutes; GRADE not reported.

1 finding from 1 review

Yangyin-humo decoction vs Traditional Western medicine

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Yangyin-humo decoction showed no clear difference in oral mucositis (moderate to severe) compared with traditional Western medicine; GRADE not reported.

1 finding from 1 review

Clarithromycin vs no treatment

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Systemic antibiotic (clarithromycin) showed no clear difference in oral mucositis (moderate to severe) compared with no treatment; GRADE not reported.

1 finding from 1 review

Oral care protocol vs usual care or no treatment

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Oral care protocol showed no clear difference in oral mucositis (moderate to severe) compared with no treatment/usual care; GRADE not reported.

1 finding from 1 review