Mean pain score and mean ulcer size · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
A statistically significant difference was reported in mean pain score and mean ulcer size favouring the homeopathic group (P<0.05). Summary data not presented, precluding further analysis.
1 study · 100 participants
GRADE not reported
Relapse rate when medications stopped · People with erosive oral lichen planus
1 finding from 1 review
In Passeron 2007 (n=12), all participants who improved during treatment relapsed within 1 month of ceasing treatment.
1 study · 12 participants
GRADE not reported
Complete remission (no further aphthous episodes to 6 months) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
One trial at high risk of bias compared clofazimine (n=23) with placebo (n=20). The number of individuals in the clofazimine group who had no further aphthous episodes from beginning treatment until completion at 6…
1 study · 43 participants
GRADE not reported
Physician Global Assessment (cure of erosive lesions, remarkably effective) · People with erosive oral lichen planus
Radix tripterygium hypoglaucum tablet (THT) showed no clear difference in physician Global Assessment (cure of erosive lesions, remarkably… compared with tripterygium glucosides tablet (TGT); GRADE not reported.
2 findings from 1 review
Beclometasone dipropionate (systemic corticosteroid) vs Placebo or no treatment
Outcome not reported · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
The review found no eligible studies for this question.
1 finding from 1 review
Number of ulcers at end of 90-day treatment · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) showed no clear difference in number of ulcers at end of 90-day treatment compared with placebo; GRADE not reported.
1 finding from 1 review
Time to ulcer closure ‐ not reported · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
Perilla cooking oil showed no clear difference in average number of days for resolution of ulcers compared with soybean cooking oil; GRADE not reported.
1 finding from 1 review
Time to resolution of first ulcer (days) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
Montelukast (leukotriene receptor antagonist; 10 mg daily for 1… led to lower time to resolution of first ulcer (days) compared with placebo; GRADE not reported.
1 finding from 1 review
Reduction in number of flares · People of any age with erosive lichen planus affecting the oral, anogenital, and/or oesophageal regions
The review found no eligible studies for this question.
1 finding from 1 review
Pain reduction (VAS 0-10) · People with erosive oral lichen planus
Clobetasol propionate ointment 0.05% showed no clear difference in pain reduction (VAS 0-10) compared with 5% topical mesalazine gel in adhesive base; GRADE not reported.
1 finding from 1 review
Physician Global Assessment (weighted sums of ulceration, erythema, reticulation, mm2) · People with erosive oral lichen planus
1% pimecrolimus cream showed no clear difference in physician Global Assessment (weighted sums of ulceration, erythema,… compared with placebo (vehicle cream); GRADE not reported.
1 finding from 1 review
Side effects · People with erosive oral lichen planus
1 finding from 1 review
Table 3 (Side-effects). Conrotto 2006: ciclosporin - skin rashes (2), parotid swelling (1), and dyspepsia (3); clobetasol - dyspepsia (1).
1 study · 40 participants
GRADE not reported
Any topical or systemic intervention vs Placebo, no treatment, or another intervention
Outcome not reported · People with erosive oesophageal lichen planus
The review found no eligible studies for this question.
1 finding from 1 review
Pain, number of ulcers, ulcer-free days and ulcer size · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
A single trial at high risk of bias compared pentoxifylline 400 mg three times daily (n=14) with placebo (n=12). No statistically significant differences were reported for pain, number of ulcers and ulcer-free days at…
1 study · 26 participants
GRADE not reported
Physician Global Assessment (Thongprasom score) · People with erosive oral lichen planus
Aloe vera gel showed no clear difference in physician Global Assessment (Thongprasom score) compared with placebo; GRADE not reported.
1 finding from 1 review
Complete remission (no further aphthous episodes to 6 months) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
The trial by de Abreu 2009 (high risk of bias) also assessed colchicine (n=23) versus placebo (n=20). The number with no further aphthous episodes at 6 months was not significantly different from placebo (Fisher's…
1 study · 43 participants
GRADE not reported
Primary outcome: partial clinical response · People with erosive oral lichen planus
Aloe vera gel led to higher partial response (>=50% clinical improvement) compared with placebo; GRADE not reported.
1 finding from 1 review
Side effects · People with erosive oral lichen planus
1 finding from 1 review
Table 3 (Side-effects). Choonhakarn 2008: no serious side-effects; 2 participants receiving aloe vera gel reported stinging and mild itching at lesions within the first week, symptoms spontaneously disappeared with…
1 study · 45 participants
GRADE not reported
Pain free by end of study (day 6) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
Individualised homeopathic medicine (two doses over 24 hours) led to higher pain free by end of study (day 6) compared with placebo; GRADE not reported.
1 finding from 1 review
Investigator‐ or physician‐rated global assessment of disease severity · People with erosive oral lichen planus
Betamethasone oral mini-pulse therapy led to higher physician Global Assessment (clinical severity, 0-12 score) compared with topical triamcinolone acetonide 0.1% paste; GRADE not reported.
1 finding from 1 review