Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,032 questions · 3,358 findings · 190 reviews · Oral Health · related questions CL0289

No studies found 599 · 17.8%GRADE not reported 1,759 · 52.4%Very low 612 · 18.2%Low 269 · 8%Moderate 107 · 3.2%High 12 · 0.4%

CAD/CAM nitinol fixed (bonded) retainer vs Multistrand / spiral wire fixed (bonded) retainer

Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment

It is very uncertain whether CAD/CAM nitinol fixed (bonded) retainer changes stability: Little's Irregularity Index (lower arch) compared with conventional/analogue multistrand fixed (bonded) retainer (very low certainty).

1 finding from 1 review

Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment

Overall treatment time wearing orthodontic appliances · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances

Light vibrational forces (LVF) showed no clear difference in duration of orthodontic treatment compared with conventional orthodontic appliance treatment (placebo or no adjunct) (low certainty).

1 finding from 1 review

Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment

Total number of orthodontic appliance adjustment appointments during treatment · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances

Light vibrational forces (LVF) showed no clear difference in total number of orthodontic appliance adjustment appointments during… compared with conventional orthodontic appliance treatment (placebo or no adjunct) (low certainty).

1 finding from 1 review

Full-time wear of removable retainer (any type) vs Part-time wear of removable retainer (any type)

Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment

It is very uncertain whether full-time wear of removable retainer (any type) changes stability: Little's Irregularity Index (lower arch) compared with part-time wear of removable retainer (any type) (very low certainty).

1 finding from 1 review

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

Locoregional recurrence · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)

PET-CT following chemoradiotherapy (neck dissection only if… showed no clear difference in locoregional recurrence compared with planned neck dissection before or after chemoradiotherapy (moderate certainty).

1 finding from 1 review

Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection

Locoregional recurrence · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes

Elective neck dissection (at time of primary tumour resection) probably leads to lower locoregional recurrence compared with therapeutic (delayed) neck dissection (moderate certainty).

1 finding from 1 review

Elective radical (comprehensive) neck dissection vs Elective selective neck dissection

Recurrence · Adults with oral cavity cancer

It is very uncertain whether elective radical (comprehensive) neck dissection changes recurrence compared with elective selective neck dissection (very low certainty).

1 finding from 1 review

Full-time clear plastic (removable) retainer vs Any type of fixed (bonded) retainer

Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment

It is very uncertain whether full-time clear plastic (removable) retainer changes stability: Little's Irregularity Index (lower arch) compared with any type of fixed (bonded) retainer (very low certainty).

1 finding from 1 review

Biodentine vs Mineral trioxide aggregate (MTA)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy

MTA and Biodentine performed comparably for clinical and radiographic success (5 RCTs, not pooled; ungraded).

1 finding from 1 review

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in mature permanent teeth

MTA increases clinical and radiographic success versus CH in mature teeth (moderate certainty).

1 finding from 1 review

Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection

Mortality (overall survival) · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes

Elective neck dissection (at time of primary tumour resection) probably leads to lower mortality (overall survival) compared with therapeutic (delayed) neck dissection (moderate certainty).

1 finding from 1 review

Sentinel node biopsy (neck dissection only if biopsy positive) vs Elective neck dissection

Disease-free survival · Adults with oral cavity or oropharyngeal cancer

Sentinel node biopsy (neck dissection only if biopsy positive) showed no clear difference in disease-free survival (new disease, progression, and mortality) compared with elective neck dissection (low certainty).

1 finding from 1 review

Superselective neck dissection vs Elective selective neck dissection

Locoregional recurrence · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes
1 finding from 1 review

Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection

Disease-free survival · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes

Elective neck dissection (at time of primary tumour resection) probably leads to lower disease-free survival (new disease, progression, and mortality) compared with therapeutic (delayed) neck dissection (moderate certainty).

1 finding from 1 review

Light-emitting diode (LED) photobiomodulation vs Conventional orthodontic appliance treatment

Duration of orthodontic treatment: alignment stage (mandibular arch) · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment

It is very uncertain whether light-emitting diode (LED) photobiomodulation changes duration of orthodontic treatment: alignment stage (mandibular arch) compared with conventional orthodontic appliance treatment (very low certainty).

1 finding from 1 review

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

Disease-free survival · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)
1 finding from 1 review