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Evidence found and GRADE certainty

3,032 questions · 3,358 findings · 190 reviews · Oral Health · related questions CL0289

No studies found 599 · 17.8%GRADE not reported 1,759 · 52.4%Very low 612 · 18.2%Low 269 · 8%Moderate 107 · 3.2%High 12 · 0.4%

Occlusal splint vs Transcutaneous electric nerve stimulation (TENS)

Clicks in TMJ on oral opening and closing · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…

Occlusal splint showed no clear difference in clicks in TMJ on oral opening and closing compared with transcutaneous electric nerve stimulation (TENS); GRADE not reported.

2 findings from 1 review

Occlusal splint vs no treatment

Increase in the size of wear facets (canine teeth) · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…

Occlusal splint showed no clear difference in increase in the size of wear facets (canine teeth) compared with no treatment; GRADE not reported.

2 findings from 1 review

Occlusal splint vs Palatal splint

Arousal index · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…

Occlusal splint showed no clear difference in arousal index compared with palatal splint; GRADE not reported.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Length of hospital stay · Patients with cancer receiving chemotherapy and/or radiotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Potassium nitrate/dimethyl isosorbide/polycarboxylate cement (KNO3/DMI/PCa) vs Potassium nitrate/polycarboxylate cement (KNO3/PCa)

Clinical success (absence of periapical pathology, tenderness to pressure and fistula formation) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Hodosh 2003 (Analysis 3.1): all 18 patients receiving KNO3/DMI/PCa responded favourably (0/18 developed clinical symptoms) versus 9/17 in the KNO3/PCa group; symptomatic teeth required endodontic therapy or extraction.…
    1 study · 35 participants
    GRADE not reported

Occlusal splint vs Placebo

Outcome not reported · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…

The review found no eligible studies for this question.

1 finding from 1 review

Occlusal splint vs Palatal splint

Episodes with grinding noise · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…

Occlusal splint showed no clear difference in episodes with grinding noise compared with palatal splint; GRADE not reported.

1 finding from 1 review

Occlusal splint vs Mandibular advancement device

Number of bruxism episodes per hour of sleep (Epi/h) · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…

Occlusal splint showed no clear difference in sleep bruxism episodes per hour of sleep compared with mandibular advancement device; GRADE not reported.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Death associated with fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole,… showed no clear difference in death associated with fungal infection compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Oral paracetamol vs placebo

At least 50% reduction in pain · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local…

Paracetamol (single oral dose, any dose or formulation; subgroups up… led to higher achieving at least 50% pain relief at 4 hours (using pain intensity… compared with placebo; GRADE not reported.

3 findings from 1 review

Occlusal splint vs Transcutaneous electric nerve stimulation (TENS)

Headache · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…
1 finding from 1 review
  • Occlusal splint versus TENS, headaches (Alvarez-Arenal 2002): the event did not occur in either group, so the risk ratio was not estimable (Risk Ratio, M-H, Fixed, 95% CI; subtotals only).
    1 study
    GRADE not reported

Occlusal splint vs Mandibular advancement device

Preference (device preferred by participants) · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…
1 finding from 1 review
  • Occlusal splint versus mandibular advancement device, preference (Landry 2006): 12 of 13 participants preferred the occlusal splint over the mandibular advancement device (MAD free); a higher proportion of benefitted…
    1 study
    GRADE not reported

Cast post and core with a diaphragm vs Cast post and core without a diaphragm

Outcome not reported · Participants with permanent endodontically-treated (root-filled) teeth for which a post is indicated to retain the final restoration

The review found no eligible studies for this question.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs Antifungal drugs not absorbed from GI tract

Empirical antifungal treatment · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract showed no clear difference in empirical antifungal treatment compared with antifungal drugs not absorbed from GI tract; GRADE not reported.

1 finding from 1 review

Potassium nitrate/dimethyl isosorbide/polycarboxylate cement (KNO3/DMI/PCa) vs Polycarboxylate cement (PCa) alone

Clinical success (absence of periapical pathology, tenderness to pressure and fistula formation) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Hodosh 2003 (Analysis 3.1): all 18 patients receiving KNO3/DMI/PCa responded favourably (0/18 developed clinical symptoms) versus 10/12 in the PCa group. "The results in groups two and three were statistically…
    1 study · 30 participants
    GRADE not reported

Glycerrhetinic acid/antibiotic mixture vs Zinc oxide and eugenol (ZOE)

Clinical success (survival free of symptoms) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Shovelton 1971 (Analysis 1.1): 275 teeth followed for 2 years (235 at 6 months, 160 at 12 months, 85 analysed at 24 months). Success rates 50% to 80%. Ledermix and calcium hydroxide had the highest success rates,…
    1 study · 275 participants
    GRADE not reported