Findings

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Evidence found and GRADE certainty

2,916 questions · 3,207 findings · 167 reviews · related questions CL0289

No studies found 596 · 18.6%GRADE not reported 1,666 · 51.9%Very low 603 · 18.8%Low 252 · 7.9%Moderate 78 · 2.4%High 12 · 0.4%

Traditional iliac bone graft plus fibrin glue vs Traditional iliac bone graft alone

Wound infection · Patients aged 7 to 16 years with unilateral or bilateral cleft lip and palate (alveolar cleft)

Traditional iliac bone graft plus fibrin glue showed no clear difference in postoperative complication: wound infection compared with traditional iliac bone graft alone; GRADE not reported.

1 finding from 1 review

Oxygenated glycerol triester (OGT) spray vs Saliveeze (aqueous electrolyte) spray

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…

Oxygenated glycerol triester (OGT) spray led to higher xerostomia (mouth dryness scale) compared with saliveeze (aqueous electrolyte) spray; GRADE not reported.

1 finding from 1 review

Mucin spray (Saliva Orthana) vs Placebo spray (base without mucin)

Patient satisfaction / desire to continue treatment · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…

Mucin spray (Saliva Orthana) led to lower patient satisfaction / desire to continue treatment compared with placebo spray (base without mucin); GRADE not reported.

1 finding from 1 review
  • Sweeney 1997: majority in both groups wished to continue the allocated spray, no significant difference (Analysis 1.3). Duxbury 1989: 14/30 (46.6%) and 15/30 (50%) wished to continue Saliva Orthana and the spray base…
    2 studies
    GRADE not reported

CMC spray / HCC spray / HCC gel vs Liquid margarine (and between each other)

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
  • Furumoto 1998 (crossover, n=28, medians/IQR): median day-10 oral dryness (lower = less dry): CMC spray 28.00 (3.06), HCC spray 28.75 (2.23), HCC gel 27.75 (3.62), margarine 29.25 (5.06). Only HCC gel showed a…
    1 study · 28 participants
    GRADE not reported

Cryotherapy (ice chips) 30 minutes vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Cryotherapy (ice chips) 30 minutes showed no clear difference in oral mucositis (moderate to severe) compared with cryotherapy (ice chips) 60 minutes; GRADE not reported.

1 finding from 1 review

Squeezable (modified) feeding bottle vs Rigid feeding bottle

Length (cm) · Infants up to 6 months (from term) born with cleft lip, cleft palate or cleft lip and palate (Pierre Robin sequence or other syndromes…

Squeezable (modified) feeding bottle showed no clear difference in length (cm) compared with rigid feeding bottle; GRADE not reported.

1 finding from 1 review

Yangyin-humo decoction vs Traditional Western medicine

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Yangyin-humo decoction showed no clear difference in oral mucositis (moderate to severe) compared with traditional Western medicine; GRADE not reported.

1 finding from 1 review

Clarithromycin vs no treatment

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Systemic antibiotic (clarithromycin) showed no clear difference in oral mucositis (moderate to severe) compared with no treatment; GRADE not reported.

1 finding from 1 review

Oral care protocol vs usual care or no treatment

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Oral care protocol showed no clear difference in oral mucositis (moderate to severe) compared with no treatment/usual care; GRADE not reported.

1 finding from 1 review

Intraoral device releasing Biotene Oral Balance gel vs Manually administered bolus of the same gel

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…

Intraoral device releasing Biotene Oral Balance gel led to lower xerostomia (Xerostomia Inventory) compared with manually administered bolus of the same gel; GRADE not reported.

1 finding from 1 review

Arthroscopy vs open surgery

Maximum protrusion over 5 mm (clinical evaluation, 12 months) · Adults (older than 18 years) with a temporomandibular disorder (synovitis, disc displacement with or without reduction, myofascial…

Arthroscopy showed no clear difference in maximum protrusion over 5 mm (clinical evaluation, 12 months) compared with open surgery; GRADE not reported.

1 finding from 1 review

Arthroscopy vs open surgery

Interincisal opening over 35 mm (clinical evaluation, 12 months) · Adults (older than 18 years) with a temporomandibular disorder (synovitis, disc displacement with or without reduction, myofascial…

Arthroscopy showed no clear difference in interincisal opening over 35 mm (clinical evaluation, 12 months) compared with open surgery; GRADE not reported.

1 finding from 1 review