What do systematic reviews say?

Guided tissue regeneration (GTR) with bovine bone mineral + resorbable collagen membrane vs No GTR (no grafting)

Guided tissue regeneration (GTR) with bovine bone mineral +… showed no clear difference in healing - 1 year compared with no GTR (no grafting) (low certainty).

• Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes

  1 year
  RR 1.12 [0.86, 1.46]
  1 study · 59 participants
  Low

Mineral trioxide aggregate (MTA) root-end filling vs Gutta-percha smoothing (orthograde GP root filling)

Mineral trioxide aggregate (MTA) root-end filling showed no clear difference in postoperative pain (VAS 0-100) - 1 day compared with gutta-percha smoothing (orthograde GP root filling) (low certainty).

• Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes

  1 day
  MD -4.00 [-16.69, 8.69]
  1 study · 42 participants
  Low

Surgical microscope (magnification) vs Endoscope

Surgical microscope (magnification) showed no clear difference in healing - 2 years (microscope vs endoscope) compared with endoscope (low certainty).

• Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes

  2 years
  RR 1.01 [0.89, 1.15]
  1 study · 70 participants
  Low

Root-end resection (with or without root-end filling; surgical retreatment) vs Non-surgical re-treatment (orthograde root canal therapy)

• Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes

  first postoperative week
  Significantly higher number of participants reporting swelling in the root-end resection group than in the root canal retreatment group during the first postoperative week (Analysis 1.5); per-day totals not pooled.
  1 study
  GRADE not reported

Root-end resection (with or without root-end filling; surgical retreatment) vs Non-surgical re-treatment (orthograde root canal therapy)

Root-end resection (with or without root-end filling; surgical… may leads to higher prevalence of pain - 1 day (participants reporting pain) compared with root canal retreatment (non-surgical/orthograde) (low certainty).

• Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes

  1 day (first postoperative week)
  RR 3.34 [2.05, 5.43]
  1 study · 87 participants
  Low

Mineral trioxide aggregate (MTA) root-end filling vs Gutta-percha smoothing (orthograde GP root filling)

Mineral trioxide aggregate (MTA) root-end filling may leads to higher healing - 1 year compared with gutta-percha smoothing (orthograde GP root filling) (low certainty).

• Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes

  1 year
  RR 1.60 [1.14, 2.24]
  1 study · 46 participants
  Low

Root-end resection (with or without root-end filling; surgical retreatment) vs Non-surgical re-treatment (orthograde root canal therapy)

It is very uncertain whether root-end resection (with or without root-end filling; surgical… changes healing - 1 year compared with root canal retreatment (non-surgical/orthograde) (very low certainty).

• Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes

  1 year
  RR 1.15 [0.97, 1.35]
  2 studies · 126 participants
  Very low

Ultrasonic device for root-end preparation vs Conventional bur

Ultrasonic device for root-end preparation showed no clear difference in healing - 1 year compared with conventional bur (low certainty).

• Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes

  1 year
  RR 1.14 [1.00, 1.30]
  1 study · 290 participants
  Low

Mineral trioxide aggregate (MTA) root-end filling vs Intermediate restorative material (IRM)

Mineral trioxide aggregate (MTA) root-end filling showed no clear difference in healing - 1 year compared with intermediate restorative material (IRM) (low certainty).

• Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes

  1 year
  RR 1.09 [0.97, 1.21]
  2 studies · 222 participants
  Low

Surgical loupes (magnification) vs Endoscope

Surgical loupes (magnification) showed no clear difference in healing - 1 year (loupes vs endoscope) compared with endoscope (low certainty).

• Endodontic procedures for retreatment of periapical lesions 2016 · Cochrane All outcomes

  1 year
  RR 1.05 [0.92, 1.20]
  1 study · 62 participants
  Low

Repositioning of ankylosed teeth after osteotomy followed or not by distraction osteogenesis, or after luxation vs Conventional orthodontic treatment or follow-up with no specific treatment for ankylosis

The review found no eligible studies for this question.

• Interventions for treating traumatised ankylosed permanent front teeth 2015 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Root canal medications and canal filling, splinting, extraction of teeth, or surgical removal of any relevant pathology vs Each other, placebo, or no treatment

The review found no eligible studies for this question.

• Interventions for the management of external root resorption 2015 · Cochrane All outcomes

  Any follow-up period
  None of the studies fulfilled our inclusion criteria and therefore no data analysis was conducted. (Main results: no RCTs that met the inclusion criteria were identified; one ongoing study, NCT00423956, potentially…
  0 studies
  No studies found

Transplantation of other teeth after extraction of the ankylosed teeth vs Conventional orthodontic treatment or follow-up with no specific treatment for ankylosis

The review found no eligible studies for this question.

• Interventions for treating traumatised ankylosed permanent front teeth 2015 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Fixed prostheses cemented to prepared teeth after extraction or decoronation of the ankylosed teeth vs Conventional orthodontic treatment or follow-up with no specific treatment for ankylosis

The review found no eligible studies for this question.

• Interventions for treating traumatised ankylosed permanent front teeth 2015 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Antibiotics (systemic) vs No antibiotics, placebo, or a different type of antibiotic

The review found no eligible studies for this question.

• Interventions for treating traumatised permanent front teeth: luxated (dislodged) teeth 2013 · Cochrane All outcomes

  Minimum 12 months follow-up
  Types of antibiotics: the effect of using no antibiotics, a placebo or different types of antibiotics. Main results: No randomised or quasi-randomised controlled trials were found; no study was included in this review.
  0 studies
  No studies found

Dental repositioning vs Spontaneous re-eruption, orthodontic repositioning, or surgical repositioning

The review found no eligible studies for this question.

• Interventions for treating traumatised permanent front teeth: luxated (dislodged) teeth 2013 · Cochrane All outcomes

  Minimum 12 months follow-up
  Types of dental repositioning: to compare spontaneous re-eruption, orthodontic repositioning or surgical repositioning. Main results: No randomised or quasi-randomised controlled trials were found; no study was…
  0 studies
  No studies found

Root canal medicaments vs No medicaments, placebo, or a different type of medicament

The review found no eligible studies for this question.

• Interventions for treating traumatised permanent front teeth: luxated (dislodged) teeth 2013 · Cochrane All outcomes

  Minimum 12 months follow-up
  Types of root canal medicaments: this was compared with no medicaments, placebo and different types of medicaments. Main results: No randomised or quasi-randomised controlled trials were found; no study was included in…
  0 studies
  No studies found

Fixation (splinting) vs No splint, or a different type or duration of splint

The review found no eligible studies for this question.

• Interventions for treating traumatised permanent front teeth: luxated (dislodged) teeth 2013 · Cochrane All outcomes

  Minimum 12 months follow-up
  Types and duration of fixation: the effect of using no splint or different types of splints and their duration. Main results: No randomised or quasi-randomised controlled trials were found; no study was included in…
  0 studies
  No studies found

Sodium hypochlorite (NaOCl), 2.5% to 5.25% vs Sodium hypochlorite 1%

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found