What do systematic reviews say?

211 questions · 317 findings · 16 reviews · Periodontology · related questions CL0289

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No studies found 44 · 13.9%GRADE not reported 184 · 58%Very low 59 · 18.6%Low 21 · 6.6%Moderate 5 · 1.6%High 4 · 1.3%

Enamel matrix derivative (EMD; Emdogain) vs Guided tissue regeneration (GTR) with barriers

Aesthetics · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…

The review found no eligible studies for this question.

1 finding from 1 review

Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes
1 year (time-points 1, 5 and 10 years planned)
SoF (Emdogain vs GTR): Aesthetics - See comment; 0 [0]; No studies reported this.
0 studies
No studies found

Enamel matrix derivative (EMD; Emdogain) vs Various bone grafting (BG) procedures (animal-derived or synthetic bone / bioactive ceramic filler)

Change in probing pocket depth (PPD) · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…

1 finding from 1 review

Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes
1 year (time-points 1, 5 and 10 years planned)
No statistically significant differences (one trial, Leknes 2009).
1 study
GRADE not reported

Enamel matrix derivative (EMD; Emdogain) vs Various bone grafting (BG) procedures (animal-derived or synthetic bone / bioactive ceramic filler)

Tooth loss · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…

1 finding from 1 review

Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes
1 year (time-points 1, 5 and 10 years planned)
No teeth were lost in either group.
1 study
GRADE not reported

Enamel matrix derivative (EMD; Emdogain) vs placebo or control

PAL gain < 2 mm (dichotomous) · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…

Enamel matrix derivative (EMD; Emdogain) led to lower PAL gain < 2 mm (dichotomous) compared with placebo or control (same surgical or non-surgical intervention…; GRADE not reported.

1 finding from 1 review

Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes
1 year (time-points 1, 5 and 10 years planned)
RR 0.53 [0.34, 0.82]
6 studies
GRADE not reported

Systemic oral acyclovir vs placebo or no treatment

Duration and time of healing of intraoral (oral) lesions; number of individuals with oral lesions · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)

Systemic oral acyclovir led to lower number of individuals with oral lesions (8 days after… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Acyclovir for treating primary herpetic gingivostomatitis 2008 · Cochrane All outcomes
8 days after administration
RR 0.10 [0.02, 0.38]
1 study · 72 participants
GRADE not reported

Systemic oral acyclovir vs placebo or no treatment

Duration and time of healing of extraoral lesions; development of new extraoral lesions · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)

Systemic oral acyclovir led to lower number of individuals who developed new extraoral lesions after… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Acyclovir for treating primary herpetic gingivostomatitis 2008 · Cochrane All outcomes
After administration
RR 0.04 [0.00, 0.65]
1 study · 72 participants
GRADE not reported

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

Change in probing pocket depth (PPD) · Adults with chronic periodontitis

Occlusal adjustment as an adjunct to non-surgical periodontal therapy showed no clear difference in probing (pocket) depth change (difference in mean reduction, mm) compared with non-surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

1 finding from 1 review

Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes
2 years
MD 0.04 [-0.19, 0.27]
1 study · 50 participants
GRADE not reported

Systemic oral acyclovir vs placebo or no treatment

Number of individuals with eating difficulties (8 days after administration); duration of eating difficulties · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)

Systemic oral acyclovir led to lower number of individuals with eating difficulties (8 days after… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Acyclovir for treating primary herpetic gingivostomatitis 2008 · Cochrane All outcomes
8 days after administration
RR 0.14 [0.03, 0.58]
1 study · 72 participants
GRADE not reported

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

Tooth loss · Adults with chronic periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes
Minimum 3 months (planned)
no estimate extracted
0 studies
No studies found

Systemic oral acyclovir vs placebo or no treatment

Difficulty in drinking (number with drinking difficulties) · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)

Systemic oral acyclovir led to lower number of individuals with drinking difficulties (8 days after… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Acyclovir for treating primary herpetic gingivostomatitis 2008 · Cochrane All outcomes
8 days after administration
RR 0.11 [0.01, 0.83]
1 study · 72 participants
GRADE not reported

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

Tooth loss · Adults with chronic periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes
Minimum 3 months (planned)
no estimate extracted
0 studies
No studies found

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

Attachment change · Adults with chronic periodontitis

Occlusal adjustment as an adjunct to surgical periodontal therapy led to higher clinical attachment level change (mean gain, mm) compared with surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

1 finding from 1 review

Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes
2 years
MD 0.40 [0.05, 0.75]
1 study · 50 participants
GRADE not reported

Systemic oral acyclovir vs placebo or no treatment

Number of individuals admitted to hospital after administration · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)

Systemic oral acyclovir showed no clear difference in number of individuals admitted to hospital after administration compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Acyclovir for treating primary herpetic gingivostomatitis 2008 · Cochrane All outcomes
After administration
RR 0.14 [0.01, 2.67]
1 study · 72 participants
GRADE not reported

Systemic oral acyclovir vs placebo or no treatment

Duration of fever · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)

1 finding from 1 review

Acyclovir for treating primary herpetic gingivostomatitis 2008 · Cochrane All outcomes
Amir 1997b: fever disappeared significantly earlier with acyclovir (median 1 day) than placebo (median 3 days); difference in median (95% CI): From 72: 1 (0.0 to 2.0); From 61: 2 (0.8 to 3.2); reported as median, not…
2 studies
GRADE not reported

One type of occlusal intervention as an adjunct to periodontal therapy vs A different type of occlusal intervention as an adjunct to periodontal therapy (head-to-head)

Outcome not reported · Adults (aged 18 years or older) with a clinical diagnosis of (chronic) periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes
Minimum 3 months (planned)
no estimate extracted
0 studies
No studies found

Occlusal intervention as an adjunct to periodontal therapy vs Sham (placebo) occlusal intervention as an adjunct to periodontal therapy

Outcome not reported · Adults (aged 18 years or older) with a clinical diagnosis of (chronic) periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes
Minimum 3 months (planned)
no estimate extracted
0 studies
No studies found

Systemic oral acyclovir vs placebo or no treatment

Mean time to resolution of pain · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)

1 finding from 1 review

Acyclovir for treating primary herpetic gingivostomatitis 2008 · Cochrane All outcomes
Amir 1997b: no data available. Ducoulombier 1988: time to resolution of pain, acyclovir (1 day=1, 2 days=1, 3 days=3, 4 days=3, 5 days=1, persistent=0) vs placebo (1 day=0, 2 days=0, 3 days=1, 4 days=2, 5 days=4,…
1 study · 18 participants
GRADE not reported

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

Change in probing pocket depth (PPD) · Adults with chronic periodontitis

Occlusal adjustment as an adjunct to surgical periodontal therapy showed no clear difference in probing (pocket) depth change (difference in mean reduction, mm) compared with surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

1 finding from 1 review

Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes
2 years
MD 0.01 [-0.20, 0.22]
1 study · 50 participants
GRADE not reported

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

Attachment change · Adults with chronic periodontitis

Occlusal adjustment as an adjunct to non-surgical periodontal therapy led to higher clinical attachment level change (mean gain, mm) compared with non-surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

1 finding from 1 review

Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes
2 years
MD 0.38 [0.04, 0.72]
1 study · 50 participants
GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Sites failing to gain 2 mm attachment (proportion) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to lower sites failing to gain 2 mm attachment (proportion) compared with open flap debridement (access flap surgery); GRADE not reported.

1 finding from 1 review

Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
>=12 months
RR 0.54 [0.31, 0.96]
6 studies
GRADE not reported