What do systematic reviews say?

13 questions · 13 findings · 1 reviews · Skin · related questions CL0289

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1% pimecrolimus cream vs Placebo (vehicle cream)

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Passeron 2007: 1% pimecrolimus well-tolerated, transient burning (2) during the first 2 weeks. Swift 2005: pimecrolimus - slight burning of the tip of the tongue after applying 1% pimecrolimus…
3 studies · 52 participants
GRADE not reported

Betamethasone oral mini-pulse therapy vs Topical triamcinolone acetonide paste

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Malhotra 2008: betamethasone oral mini-pulse - transient oedema over the face (7), oedema over hands and feet (4), epigastric discomfort (7), weakness/fatigue (5), loose stools (1), headache…
1 study · 22 participants
GRADE not reported

Clobetasol-17-propionate 0.025% lipid-loaded microspheres vs Clobetasol propionate 0.025% ointment

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Campisi 2004: oral candidiasis (1 in the lipid-loaded microspheres group, 2 in the conventional ointment group). None serious.
1 study · 50 participants
GRADE not reported

Tacrolimus 0.1% vs Topical clobetasol propionate 0.05% ointment

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Radfar 2008: burning sensation with topical tacrolimus; transient burning within the first 2 weeks resulted in withdrawal of therapy in 1 participant.
1 study · 29 participants
GRADE not reported

Topical ciclosporin 1.5% gel vs Topical clobetasol propionate 0.025% gel

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Conrotto 2006: ciclosporin - skin rashes (2), parotid swelling (1), and dyspepsia (3); clobetasol - dyspepsia (1).
1 study · 40 participants
GRADE not reported

Aloe vera gel vs placebo

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Choonhakarn 2008: no serious side-effects; 2 participants receiving aloe vera gel reported stinging and mild itching at lesions within the first week, symptoms spontaneously disappeared with…
1 study · 45 participants
GRADE not reported

Fluticasone propionate spray vs Betamethasone sodium phosphate mouthwash

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Hegarty 2002: nausea (4), swollen mouth (1), bad taste and smell (6), difficulty in spray application (7), dry mouth (2), sore throat (1), red painful tongue (1), and pseudomembranous…
1 study · 44 participants
GRADE not reported

Radix tripterygium hypoglaucum tablet (THT) vs Tripterygium glucosides tablet (TGT)

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Lin 2005: TGT - menstrual disturbance (6) and leucopenia (1). Tripterygium glucosides are known to be cytotoxic and unsuitable for individuals of child-bearing age.
1 study · 94 participants
GRADE not reported

Ciclosporin rinse vs Placebo (vehicle cream)

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Eisen 1990: no adverse side-effects; transient burning sensation of mucosal surfaces during swishing of medication reported in all participants.
1 study · 8 participants
GRADE not reported

0.1% triamcinolone acetonide in orabase vs ciclosporin

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Yoke 2006: no significant adverse events; transient burning sensation upon initial application with both treatments.
1 study · 15 participants
GRADE not reported

Clobetasol propionate ointment vs 5% topical mesalazine gel in adhesive base

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Sardella 1998: no side-effects (there were no reported side-effects with topical mesalazine gel).
1 study · 12 participants
GRADE not reported

Fluocinonide in adhesive base vs placebo

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Voute 1993: no side-effects during the study and follow-up period.
1 study · 27 participants
GRADE not reported

Topical clobetasol propionate 0.025% vs clobetasol cream 0.05% cream

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Carbone 2009: no side-effects.
1 study · 35 participants
GRADE not reported