What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Oral Health · related questions CL0289

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No studies found 0 · 0%GRADE not reported 7 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Topical clobetasol propionate 0.025% vs clobetasol cream 0.05% cream

Pain reduction (VAS) · People with erosive oral lichen planus

Topical clobetasol propionate 0.025% showed no clear difference in pain reduction (VAS) compared with topical clobetasol propionate 0.05%; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
MD -0.26 [-1.42, 0.90]
1 study · 30 participants
GRADE not reported

1% pimecrolimus cream vs Placebo (vehicle cream)

Pain reduction (VAS) · People with erosive oral lichen planus

1% pimecrolimus cream showed no clear difference in pain reduction (VAS) compared with placebo (vehicle cream); GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
MD -3.30 [-20.22, 13.62]
2 studies · 32 participants
GRADE not reported

Tacrolimus 0.1% vs Topical clobetasol propionate 0.05% ointment

Pain reduction (VAS 0-10) · People with erosive oral lichen planus

Topical tacrolimus 0.1% ointment showed no clear difference in pain reduction (VAS 0-10) compared with topical clobetasol propionate 0.05% ointment; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
MD -0.64 [-1.91, 0.63]
1 study · 29 participants
GRADE not reported

Clobetasol propionate ointment vs 5% topical mesalazine gel in adhesive base

Pain reduction (VAS 0-10) · People with erosive oral lichen planus

Clobetasol propionate ointment 0.05% showed no clear difference in pain reduction (VAS 0-10) compared with 5% topical mesalazine gel in adhesive base; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
MD -0.83 [-4.12, 2.46]
1 study · 12 participants
GRADE not reported

0.1% triamcinolone acetonide in orabase vs ciclosporin

Pain reduction (VAS 0-100) · People with erosive oral lichen planus

0.1% triamcinolone acetonide in orabase led to higher pain reduction (VAS 0-100) compared with ciclosporin solution; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
MD 45.17 [8.73, 81.61]
1 study · 11 participants
GRADE not reported

Fluticasone propionate spray vs Betamethasone sodium phosphate mouthwash

Pain reduction (VAS 0-100) · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
In the Hegarty 2002 cross-over trial (n=22), no statistical testing of the pain score (VAS 0 to 100) was reported; it is not clear whether the difference is statistically significant (fluticasone mean score 19.8 versus…
1 study · 22 participants
GRADE not reported

Clobetasol-17-propionate 0.025% lipid-loaded microspheres vs Clobetasol propionate 0.025% ointment

Pain reduction (VAS 0-100) · People with erosive oral lichen planus

Clobetasol-17-propionate 0.025% lipid-loaded microspheres led to lower pain reduction (VAS 0-100) compared with conventional 0.025% clobetasol lipophilic ointment in hydrophilic…; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
MD -18.30 [-28.57, -8.03]
1 study · 45 participants
GRADE not reported